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Retinotectal Plasticity in Xenopus: Anomalous lpsilateral Projection following Late Larval Eye Removal

Fraser, Scott E. and Hunt, R. K. (1980) Retinotectal Plasticity in Xenopus: Anomalous lpsilateral Projection following Late Larval Eye Removal. Developmental Biology, 79 (2). pp. 444-452. ISSN 0012-1606. doi:10.1016/0012-1606(80)90129-3. https://resolver.caltech.edu/CaltechAUTHORS:20160413-091052903

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Abstract

The left eye was removed from Stage 56 Xenopus tadpoles. Two to 9 months after metamorphosis, electrophysiologic analysis showed that the surviving (right) eye mediated a normal visual field projection to the left (contralateral) optic tectum. In addition, a peripheral region of the same retina innervated the entire right (ipsilateral) tectum. Primary evidence that indicates this anomalous ipsilateral projection was due to direct retina-to-tectum innervation comes from singleunit analysis, latency measurements, and tectal lesion studies. Thus, the peripheral retina simultaneously connected in much different patterns to the two optic tecta, solely on the basis of the presence (in the left tectum) or absence (in the right tectum) of central retinal fibers. This documents a role for fiber-fiber interaction (such as repulsion or competition) acting in combination with fiber-tectum interactions in the formation of the retinotectal map.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0012-1606(80)90129-3DOIArticle
http://www.sciencedirect.com/science/article/pii/0012160680901293PublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1980 Academic Press, Inc. Received May 14, 1979; accepted January 28, 1980. We thank Dr. M. Duda for providing histologic materials, Ms. Lucinda Hentges for preparing the manuscript, and Ms. Diana Ross for excellent technical assistance. This work was supported by grants from the U.S. National Institutes of Health (GM07231-04; NS-12606; NS-14807) and the National Science Foundation (BMS-75-18958; PCM-77-26987). Dr. Hunt is a fellow of the Alfred Sloan Foundation.
Funders:
Funding AgencyGrant Number
NIHGM07231-04
NIHNS-12606
NIHNS-14807
NSFBMS-75-18958
NSFPCM-77-26987
Alfred P. Sloan FoundationUNSPECIFIED
Issue or Number:2
DOI:10.1016/0012-1606(80)90129-3
Record Number:CaltechAUTHORS:20160413-091052903
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160413-091052903
Official Citation:Scott E. Fraser, R.K. Hunt, Retinotectal plasticity in Xenopus: Anomalous ipsilateral projection following late larval eye removal, Developmental Biology, Volume 79, Issue 2, 1980, Pages 444-452, ISSN 0012-1606, http://dx.doi.org/10.1016/0012-1606(80)90129-3. (http://www.sciencedirect.com/science/article/pii/0012160680901293)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66104
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 Apr 2016 17:16
Last Modified:10 Nov 2021 23:53

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