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A theory of the chain melting phase transition of aqueous phospholipid dispersions

Jacobs, Russell E. and Hudson, Bruce and Andersen, Hans C. (1975) A theory of the chain melting phase transition of aqueous phospholipid dispersions. Proceedings of the National Academy of Sciences of the United States of America, 72 (10). pp. 3993-3997. ISSN 0027-8424. PMCID PMC433124. http://resolver.caltech.edu/CaltechAUTHORS:20160418-092043696

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Abstract

A model for the chain melting phase transition in dilute aqueous phospholipid bilayer dispersions is presented. This model includes interactions between head groups, between hydrocarbon chains, and within the chains. The head groups are modeled as hard disks which are constrained to lie on a two-dimensional surface separating the aqueous and hydrocarbon regions. The chain statistics problem is treated in an approximate manner using an approach motivated by scaled particle theory to describe the inter-chain steric repulsions in a mathematically tractable way. In this approach the whole system interacts with any given chain through an average lateral pressure which is proportional to the hard disk pressure. Following Nagle, we assume that the steric repulsions between chains and between head groups and the trans-gauche rotation energies are the dominant interactions in determining the transition and we describe the effect of the other interactions with a mean field approximation. Using the known transition temperature of a series of 1,2-diacyl phosphatidyl cholines to adjust two parameters in the theory, the model gives enthalpy and area changes that are in quite reasonable agreement with experiment. Moreover, the curvature observed in the plot of the transition temperature against acyl chain length is reproduced.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://www.pnas.org/content/72/10/3993.abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC433124/PubMed CentralArticle
http://www.jstor.org/stable/65220JSTORArticle
ORCID:
AuthorORCID
Jacobs, Russell E.0000-0002-1382-8486
Additional Information:© 1975 National Academy of Sciences. Communicated by Harden M. McConnell, July 14, 1975. This work was partially supported by National Institutes of Health Research Grant GM 21149 to B.H. B.H. is an Alfred P. Sloan Fellow and Camille and Henry Dreyfus Teacher Scholar.
Funders:
Funding AgencyGrant Number
NIHGM 21149
Alfred P. Sloan FoundationUNSPECIFIED
Camille and Henry Dreyfus FoundationUNSPECIFIED
Subject Keywords:lipids; statistical thermodynamics
PubMed Central ID:PMC433124
Record Number:CaltechAUTHORS:20160418-092043696
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160418-092043696
Official Citation:R E Jacobs, B Hudson, and H C Andersen A theory of the chain melting phase transition of aqueous phospholipid dispersions PNAS 1975 72 (10) 3993-3997
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66234
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:18 Apr 2016 16:58
Last Modified:13 Feb 2019 18:06

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