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Programming Molecular Association and Viscoelastic Behavior in Protein Networks

Dooling, Lawrence J. and Buck, Maren E. and Zhang, Wen-Bin and Tirrell, David A. (2016) Programming Molecular Association and Viscoelastic Behavior in Protein Networks. Advanced Materials, 28 (23). pp. 4651-4657. ISSN 0935-9648.

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A set of recombinant artificial proteins that can be cross-linked, by either covalent bonds or association of helical domains or both, is described. The designed proteins can be used to construct molecular networks in which the mechanism of cross-linking determines the time-dependent responses to mechanical deformation.

Item Type:Article
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Tirrell, David A.0000-0003-3175-4596
Additional Information:© 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. Received: December 14, 2015. Revised: January 28, 2016; First published: 9 April 2016. This work was supported by the Biomaterials Program of the U. S. National Science Foundation through grant DMR1506483, and by the Gordon and Betty Moore Foundation through grant GBMF2809. Peter Rapp provided PEP protein for rheological measurements. The authors thank Julia Kornfield for allowing extensive access to the rheometer in her laboratory and Amy Fu for providing helpful advice on rheological measurements. Mona Shahgholi in the mass spectrometry facility of Caltech’s Division of Chemistry and Chemical Engineering offered expert assistance in the determination of protein molar masses.
Funding AgencyGrant Number
Gordon and Betty Moore FoundationGBMF2809
Subject Keywords:artificial proteins; hydrogels; viscoelastic networks
Issue or Number:23
Record Number:CaltechAUTHORS:20160418-105044935
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Official Citation:Dooling, L. J., Buck, M. E., Zhang, W.-B. and Tirrell, D. A. (2016), Programming Molecular Association and Viscoelastic Behavior in Protein Networks. Adv. Mater., 28: 4651–4657. doi:10.1002/adma.201506216
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66242
Deposited By: Tony Diaz
Deposited On:18 Apr 2016 18:19
Last Modified:03 Oct 2019 09:54

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