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Medial Prefrontal and Anterior Insular Connectivity in Early Schizophrenia and Major Depressive Disorder: A Resting Functional MRI Evaluation of Large-Scale Brain Network Models

Penner, Jacob and Ford, Kristen A. and Taylor, Reggie and Schaefer, Betsy and Théberge, Jean and Neufeld, Richard W. J. and Osuch, Elizabeth A. and Menon, Ravi S. and Rajakumar, Nagalingam and Allman, John M. and Williamson, Peter C. (2016) Medial Prefrontal and Anterior Insular Connectivity in Early Schizophrenia and Major Depressive Disorder: A Resting Functional MRI Evaluation of Large-Scale Brain Network Models. Frontiers in Human Neuroscience, 10 . Art. No. 132. ISSN 1662-5161. PMCID PMC4811885. https://resolver.caltech.edu/CaltechAUTHORS:20160420-111642415

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Abstract

Anomalies in the medial prefrontal cortex, anterior insulae, and large-scale brain networks associated with them have been proposed to underlie the pathophysiology of schizophrenia and major depressive disorder (MDD). In this study, we examined the connectivity of the medial prefrontal cortices and anterior insulae in 24 healthy controls, 24 patients with schizophrenia, and 24 patients with MDD early in illness with seed-based resting state functional magnetic resonance imaging analysis using Statistical Probability Mapping. As hypothesized, reduced connectivity was found between the medial prefrontal cortex and the dorsal anterior cingulate cortex and other nodes associated with directed effort in patients with schizophrenia compared to controls while patients with MDD had reduced connectivity between the medial prefrontal cortex and ventral prefrontal emotional encoding regions compared to controls. Reduced connectivity was found between the anterior insulae and the medial prefrontal cortex in schizophrenia compared to controls, but contrary to some models emotion processing regions failed to demonstrate increased connectivity with the medial prefrontal cortex in MDD compared to controls. Although, not statistically significant after correction for multiple comparisons, patients with schizophrenia tended to demonstrate decreased connectivity between basal ganglia-thalamocortical regions and the medial prefrontal cortex compared to patients with MDD, which might be expected as these regions effect action. Results were interpreted to support anomalies in nodes associated with directed effort in schizophrenia and nodes associated with emotional encoding network in MDD compared to healthy controls.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3389/fnhum.2016.00132DOIArticle
http://journal.frontiersin.org/article/10.3389/fnhum.2016.00132/fullPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811885/PubMed CentralArticle
Additional Information:© 2016 Penner, Ford, Taylor, Schaefer, Théberge, Neufeld, Osuch, Menon, Rajakumar, Allman and Williamson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Received: 25 November 2015; Accepted: 11 March 2016; Published: 30 March 2016. Author Contributions: JT, RN, EO, RM, NR, JA, and PW designed the study. JP, KF, and PW implemented all data analysis and wrote the manuscript. All authors were involved in manuscript revisions. BS performed subject coordination and clinical data acquisition. RT performed imaging data acquisition. PW is the principle investigator and performed clinical assessments. Support is acknowledged from the Canadian Institutes of Health Research, grant number 12078 and the Tanna Schulich Chair in Neuroscience and Mental Health. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Funders:
Funding AgencyGrant Number
Canadian Institutes of Health Research (CIHR)12078
Tanna Schulich Chair in Neuroscience and Mental HealthUNSPECIFIED
Subject Keywords:anterior insula, functional network connectivity, major depressive disorder, medial prefrontal cortex, resting fMRI, schizophrenia
PubMed Central ID:PMC4811885
Record Number:CaltechAUTHORS:20160420-111642415
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160420-111642415
Official Citation:Penner J, Ford KA, Taylor R, Schaefer B, Théberge J, Neufeld RWJ, Osuch EA, Menon RS, Rajakumar N, Allman JM and Williamson PC (2016) Medial Prefrontal and Anterior Insular Connectivity in Early Schizophrenia and Major Depressive Disorder: A Resting Functional MRI Evaluation of Large-Scale Brain Network Models. Front. Hum. Neurosci. 10:132. doi: 10.3389/fnhum.2016.00132
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66314
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:20 Apr 2016 18:28
Last Modified:03 Oct 2019 09:55

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