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Does bilateral damage to the human amygdala produce autistic symptoms?

Paul, Lynn K. and Corsello, Christina and Tranel, Daniel and Adolphs, Ralph (2010) Does bilateral damage to the human amygdala produce autistic symptoms? Journal of Neurodevelopmental Disorders, 2 (3). pp. 165-173. ISSN 1866-1947. PMCID PMC2914867. https://resolver.caltech.edu/CaltechAUTHORS:20160421-082247998

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Abstract

A leading neurological hypothesis for autism postulates amygdala dysfunction. This hypothesis has considerable support from anatomical and neuroimaging studies. Individuals with bilateral amygdala lesions show impairments in some aspects of social cognition. These impairments bear intriguing similarity to those reported in people with autism, such as impaired recognition of emotion in faces, impaired theory of mind abilities, failure to fixate eyes in faces, and difficulties in regulating personal space distance to others. Yet such neurological cases have never before been assessed directly to see if they meet criteria for autism spectrum disorders (ASD). Here we undertook such an investigation in two rare participants with developmental-onset bilateral amygdala lesions. We administered a comprehensive clinical examination, as well as the Autism Diagnostic Observation Schedule (ADOS), the Social Responsiveness Scale (SRS), together with several other standardized questionnaires. Results from the two individuals with amygdala lesions were compared with published norms from both healthy populations as well as from people with ASD. Neither participant with amygdala lesions showed any evidence of autism across the array of different measures. The findings demonstrate that amygdala lesions in isolation are not sufficient for producing autistic symptoms. We suggest instead that it may be abnormal connectivity between the amygdala and other structures that contributes to autistic symptoms at a network level.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s11689-010-9056-1DOIArticle
http://jneurodevdisorders.biomedcentral.com/articles/10.1007/s11689-010-9056-1PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914867/PubMed CentralArticle
ORCID:
AuthorORCID
Paul, Lynn K.0000-0002-3128-8313
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2010 The Author(s). This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. Received: 11 April 2010; Accepted: 25 June 2010; Published online: 10 July 2010. The study was funded through grants from the Simons Foundation Autism Research Initiative, and grant R01MH080721 from the National Institute of Mental Health. We thank Joe Piven for helpful comments on the manuscript.
Funders:
Funding AgencyGrant Number
Simons FoundationUNSPECIFIED
NIHR01MH080721
Issue or Number:3
PubMed Central ID:PMC2914867
Record Number:CaltechAUTHORS:20160421-082247998
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160421-082247998
Official Citation:Does bilateral damage to the human amygdala produce autistic symptoms? Lynn K. Paul, Christina Corsello, Daniel Tranel and Ralph Adolphs Journal of Neurodevelopmental Disorders20102:9056 DOI: 10.1007/s11689-010-9056-1
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66348
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:21 Apr 2016 17:10
Last Modified:03 Oct 2019 09:55

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