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Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation

Heyden, S. and Ortiz, M. (2016) Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation. Journal of the Mechanics and Physics of Solids, 92 . pp. 164-175. ISSN 0022-5096. http://resolver.caltech.edu/CaltechAUTHORS:20160502-083438790

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Abstract

We investigate a method of selectively targeting cancer cells by means of ultrasound harmonic excitation at their resonance frequency, which we refer to as oncotripsy. The geometric model of the cells takes into account the cytoplasm, nucleus and nucleolus, as well as the plasma membrane and nuclear envelope. Material properties are varied within a pathophysiologically-relevant range. A first modal analysis reveals the existence of a spectral gap between the natural frequencies and, most importantly, resonant growth rates of healthy and cancerous cells. The results of the modal analysis are verified by simulating the fully-nonlinear transient response of healthy and cancerous cells at resonance. The fully nonlinear analysis confirms that cancerous cells can be selectively taken to lysis by the application of carefully tuned ultrasound harmonic excitation while simultaneously leaving healthy cells intact.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jmps.2016.04.016DOIArticle
http://www.sciencedirect.com/science/article/pii/S0022509615303161PublisherArticle
Additional Information:© 2016 Elsevier Ltd. Received 6 December 2015, Accepted 12 April 2016, Available online 13 April 2016.
Group:GALCIT
Subject Keywords:Oncotripsy; Modal analysis; Resonance; Cell necrosis
Record Number:CaltechAUTHORS:20160502-083438790
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160502-083438790
Official Citation:S. Heyden, M. Ortiz, Oncotripsy: Targeting cancer cells selectively via resonant harmonic excitation, Journal of the Mechanics and Physics of Solids, Volume 92, July 2016, Pages 164-175, ISSN 0022-5096, http://dx.doi.org/10.1016/j.jmps.2016.04.016. (http://www.sciencedirect.com/science/article/pii/S0022509615303161)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66573
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:02 May 2016 16:01
Last Modified:05 Jan 2017 00:12

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