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Addressing single molecules on DNA nanostructures

Cohen, Justin D. and Sadowski, John P. and Dervan, Peter B. (2007) Addressing single molecules on DNA nanostructures. Angewandte Chemie International Edition, 46 (42). pp. 7956-1959. ISSN 1433-7851. doi:10.1002/anie.200702767.

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The synthesis of devices and materials from molecular components is a major goal of nanotechnology. Although many such molecular components have been demonstrated previously,1–3 the ability to combine these components into designed architectures containing significant complexity remains a challenge. By using the hybridization properties of DNA and Watson–Crick base pairing, it has been possible to create well-defined DNA architectures of increasing complexity.4 The structure of an assembled DNA complex is directly and uniquely determined by the sequence of the DNA bases, which can be designed and manipulated. These methods provide a versatile and programmable way to control the structure and architecture of DNA nanostructures.

Item Type:Article
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URLURL TypeDescription Information
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 2007 Wiley-VCH Verlag GmbH & Co. Received: June 22, 2007. We are grateful for support from the Ralph M. Parsons Foundation and W. Webster. We thank Prof. Erik Winfree and Dr. Sung Ha Park for guidance on the AFM experiments and helpful discussions.
Funding AgencyGrant Number
Ralph M. Parsons FoundationUNSPECIFIED
Subject Keywords:DNA, nanostructures, polyamides, self-assembly
Issue or Number:42
Record Number:CaltechAUTHORS:20160509-104246356
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Official Citation:Cohen, Justin D., Sadowski, John P. and Dervan, Peter B. (2007), Addressing Single Molecules on DNA Nanostructures. Angewandte Chemie International Edition, 46: 7956–7959. doi:10.1002/anie.200702767
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66743
Deposited By: Victoria Brennan
Deposited On:17 May 2016 20:15
Last Modified:11 Nov 2021 00:02

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