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Building a Science of Individual Differences from fMRI

Dubois, Julien and Adolphs, Ralph (2016) Building a Science of Individual Differences from fMRI. Trends in Cognitive Sciences, 20 (6). pp. 425-443. ISSN 1364-6613. PMCID PMC4886721. doi:10.1016/j.tics.2016.03.014.

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To date, fMRI research has been concerned primarily with evincing generic principles of brain function through averaging data from multiple subjects. Given rapid developments in both hardware and analysis tools, the field is now poised to study fMRI-derived measures in individual subjects, and to relate these to psychological traits or genetic variations. We discuss issues of validity, reliability and statistical assessment that arise when the focus shifts to individual subjects and that are applicable also to other imaging modalities. We emphasize that individual assessment of neural function with fMRI presents specific challenges and necessitates careful consideration of anatomical and vascular between-subject variability as well as sources of within-subject variability.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Dubois, Julien0000-0002-3029-173X
Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2016 Elsevier Ltd. Available online 30 April 2016. This work was funded in part by a NARSAD grant from the Brain and Behavior Research Foundation (to J.D.) and a Conte Center from the National Institute of Mental Health (NIMH) (to R.A.). The authors thank Rebecca Schwarzlose, Michael Miller, Alex Huth, Swaroop Guntupalli and two anonymous reviewers for useful comments on the manuscript.
Funding AgencyGrant Number
Brain and Behavior Research FoundationUNSPECIFIED
National Institute of Mental Health (NIMH)UNSPECIFIED
Subject Keywords:BOLD fMRI; individual differences; neurometrics; validity; reliability; prediction
Issue or Number:6
PubMed Central ID:PMC4886721
Record Number:CaltechAUTHORS:20160509-112148246
Persistent URL:
Official Citation:Julien Dubois, Ralph Adolphs, Building a Science of Individual Differences from fMRI, Trends in Cognitive Sciences, Volume 20, Issue 6, June 2016, Pages 425-443, ISSN 1364-6613,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66760
Deposited On:09 May 2016 19:56
Last Modified:28 Apr 2022 17:52

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