A Caltech Library Service

Regulation of gene expression by synthetic DNA-binding ligands

Dervan, Peter B. and Poulin-Kerstien, Adam T. and Fechter, Eric J. and Edelson, Benjamin S. (2005) Regulation of gene expression by synthetic DNA-binding ligands. In: DNA Binders and Related Subjects. Topics in Current Chemistry. No.253. Springer-Verlag Berlin , Berlin, pp. 1-31. ISBN 978-3-540-22835-6.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


During the past 20 years, polyamides have evolved from the natural product distamycin to a new class of programmable heterocyclic oligomers that bind a broad repertoire of DNA sequences with high affinity and specificity. This chapter details recent advances in this field of research, focusing on molecular recognition of DNA, and biological applications such as modulating gene expression by small molecules. Work presented here represents efforts towards the modulation of specific cellular function by small molecules in an addressable fashion within the context of live cells.

Item Type:Book Section
Related URLs:
URLURL TypeDescription
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 2005 Springer. We are grateful to the National Institutes of Health for research support. A.T.P.-K. is supported by an NIH Predoctoral Training Grant. E.J.F. is supported by an NIH Research Service Award and Ralph M. Parsons Fellowship. B.S.E. is supported by a predoctoral fellowship from the Howard Hughes Medical Institute.
Funding AgencyGrant Number
NIH Predoctoral FellowshipUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:polyamide; DNA; gene regulation
Series Name:Topics in Current Chemistry
Issue or Number:253
Record Number:CaltechAUTHORS:20160509-112818968
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66762
Deposited By: Victoria Brennan
Deposited On:17 May 2016 22:41
Last Modified:11 Nov 2021 00:02

Repository Staff Only: item control page