Dervan, Peter B. and Poulin-Kerstien, Adam T. and Fechter, Eric J. and Edelson, Benjamin S. (2005) Regulation of gene expression by synthetic DNA-binding ligands. In: DNA Binders and Related Subjects. Topics in Current Chemistry. No.253. Springer-Verlag Berlin , Berlin, pp. 1-31. ISBN 978-3-540-22835-6. https://resolver.caltech.edu/CaltechAUTHORS:20160509-112818968
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Abstract
During the past 20 years, polyamides have evolved from the natural product distamycin to a new class of programmable heterocyclic oligomers that bind a broad repertoire of DNA sequences with high affinity and specificity. This chapter details recent advances in this field of research, focusing on molecular recognition of DNA, and biological applications such as modulating gene expression by small molecules. Work presented here represents efforts towards the modulation of specific cellular function by small molecules in an addressable fashion within the context of live cells.
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| Additional Information: | © 2005 Springer. We are grateful to the National Institutes of Health for research support. A.T.P.-K. is supported by an NIH Predoctoral Training Grant. E.J.F. is supported by an NIH Research Service Award and Ralph M. Parsons Fellowship. B.S.E. is supported by a predoctoral fellowship from the Howard Hughes Medical Institute. | |||||||||
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| Subject Keywords: | polyamide; DNA; gene regulation | |||||||||
| Series Name: | Topics in Current Chemistry | |||||||||
| Issue or Number: | 253 | |||||||||
| DOI: | 10.1007/b100440 | |||||||||
| Record Number: | CaltechAUTHORS:20160509-112818968 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160509-112818968 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 66762 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 17 May 2016 22:41 | |||||||||
| Last Modified: | 11 Nov 2021 00:02 |
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