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Characterization of Barmah Forest Virus: An Alphavirus with Some Unusual Properties

Dalgarno, L. and Short, N. J. and Hardy, C. M. and Bell, J. R. and Strauss, J. H. and Marshall, I. D. (1984) Characterization of Barmah Forest Virus: An Alphavirus with Some Unusual Properties. Virology, 133 (2). pp. 416-426. ISSN 0042-6822. https://resolver.caltech.edu/CaltechAUTHORS:20160509-150830213

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Abstract

Barmah Forest virus has been characterized in a number of ways including electron microscopy of infected cells; physical studies of the virion, its RNA, and associated proteins; N-terminal sequence analysis of the two envelope glycoproteins; studies of macromolecular species present in infected cells; and serological cross-reactions with alphaviruses and bunyaviruses. From these results Barmah Forest virus is clearly an alphavirus since the structure of the virion, the mode of replication, and the macromolecular species present in infected cells are typical of alphaviruses. The N-terminal regions of the two glycoproteins El and E2 show extensive sequence homology (approximately 50%) with those of other alphaviruses. Barmah Forest virus cross-reacts in hemagglutination inhibition tests, although not in complement fixation tests or infectivity neutralization tests, with other alphaviruses. In some of its properties Barmah Forest virus is unusual, however. It cross-reacts in complement fixation and hemagglutination inhibition tests with Umbre virus, a bunyavirus, which originally led it to be classified as a bunyavirus; the glycosylation pattern of E2 of Barmah Forest virus appears to differ from that of other alphaviruses; and the sedimentation coefficient of the virion appears to be slightly less than that of other alphaviruses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0042-6822(84)90407-0DOIArticle
http://www.sciencedirect.com/science/article/pii/0042682284904070PublisherArticle
Additional Information:© 1984 Academic Press, Inc. Received October 4, 1983; accepted December 9, 1983. The authors thank Claire Larmour and Elizabeth Bruce for typing and Ester Osko and Erika Treyde for excellent technical assistance. The work was supported by a grant from the Australian Research Grants Committee and by National Institutes of Health Grants GM06965 and AI10793 from the U. S. Public Health Service.
Funders:
Funding AgencyGrant Number
Australian Research Grants CommitteeUNSPECIFIED
NIHGM-06965
NIHAI-10793
Issue or Number:2
Record Number:CaltechAUTHORS:20160509-150830213
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160509-150830213
Official Citation:L. Dalgarno, N.J. Short, C.M. Hardy, J.R. Bell, J.H. Strauss, I.D. Marshall, Characterization of Barmah Forest virus: An alphavirus with some unusual properties, Virology, Volume 133, Issue 2, 1984, Pages 416-426, ISSN 0042-6822, http://dx.doi.org/10.1016/0042-6822(84)90407-0. (http://www.sciencedirect.com/science/article/pii/0042682284904070)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66784
Collection:CaltechAUTHORS
Deposited By: Donna Wrublewski
Deposited On:09 May 2016 23:58
Last Modified:03 Oct 2019 10:00

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