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Ross River virus 26 S RNA: Complete nucleotide sequence and deduced sequence of the encoded structural proteins

Dalgarno, Lynn and Rice, Charles M. and Strauss, James H. (1983) Ross River virus 26 S RNA: Complete nucleotide sequence and deduced sequence of the encoded structural proteins. Virology, 129 (1). pp. 170-187. ISSN 0042-6822.

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The complete sequence of the 26 S RNA of Ross River virus (T48 strain) has been obtained and from this the amino acid sequences of the encoded structural proteins have been deduced. These include a basic capsid protein and two envelope glycoproteins. The nucleotide sequence was obtained by chemical sequence analysis of both single-stranded and double-stranded cDNA made to RNA and the sequence data so obtained was rapidly aligned by making use of the protein homology found among the alphaviruses. The polyprotein precursor encoded by the 26 S RNA of Ross River virus is 75% homologous to that of Semliki Forest virus and 48% homologous to that of Sindbis virus. The extent of homology is not uniform within a protein or between proteins and this is discussed with respect to the possible function of the various polypeptide domains in the virus life cycle. In each case the putative attachment site of the amino proximal carbohydrate chains of the three glycoproteins is conserved, whereas the attachment site of a second chain, if present, is not conserved. The 3'-untranslated region of Ross River virus RNA is 524 nucleotides long. It contains a sequence of about 50 nucleotides in length which is present in four copies but which is not shared with other alphaviruses examined.

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Additional Information:© 1983 Academic Press, Inc. Received March 3, 1983; accepted May 19, 1983. We thank E. Lenches for expert technical assistance in preparation of cells and of virus stocks. The computer programs used in this work were written by T. Hunkapiller and we are grateful to him for access to these programs and for help in their use and to L. Hood for use of the computer facilities. This work was supported in part by Grants GM 06965 and AI 10793 from the NIH and Grant PCM 8022830 from the NSF.
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NSFPCM 8022830
Issue or Number:1
Record Number:CaltechAUTHORS:20160509-150830878
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Official Citation:Lynn Dalgarno, Charles M. Rice, James H. Strauss, Ross river virus 26 S RNA: Complete nucleotide sequence and deduced sequence of the encoded structural proteins, Virology, Volume 129, Issue 1, 1983, Pages 170-187, ISSN 0042-6822, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66786
Deposited By: Donna Wrublewski
Deposited On:09 May 2016 23:07
Last Modified:03 Oct 2019 10:00

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