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Design Principles of Length Control of Cytoskeletal Structures

Mohapatra, Lishibanya and Goode, Bruce L. and Jelenkovic, Predrag and Phillips, Rob and Kondev, Jane (2016) Design Principles of Length Control of Cytoskeletal Structures. Annual Review of Biophysics, 45 . pp. 85-116. ISSN 1936-122X. PMCID PMC5466818. doi:10.1146/annurev-biophys-070915-094206. https://resolver.caltech.edu/CaltechAUTHORS:20160509-153942313

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Abstract

Cells contain elaborate and interconnected networks of protein polymers, which make up the cytoskeleton. The cytoskeleton governs the internal positioning and movement of vesicles and organelles and controls dynamic changes in cell polarity, shape, and movement. Many of these processes require tight control of the size and shape of cytoskeletal structures, which is achieved despite rapid turnover of their molecular components. Here we review mechanisms by which cells control the size of filamentous cytoskeletal structures, from the point of view of simple quantitative models that take into account stochastic dynamics of their assembly and disassembly. Significantly, these models make experimentally testable predictions that distinguish different mechanisms of length control. Although the primary focus of this review is on cytoskeletal structures, we believe that the broader principles and mechanisms discussed herein will apply to a range of other subcellular structures whose sizes are tightly controlled and are linked to their functions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1146/annurev-biophys-070915-094206DOIArticle
http://www.annualreviews.org/doi/suppl/10.1146/annurev-biophys-070915-094206PublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466818PubMed CentralArticle
https://arxiv.org/abs/1701.05473arXivDiscussion Paper
ORCID:
AuthorORCID
Mohapatra, Lishibanya0000-0003-4332-1675
Goode, Bruce L.0000-0002-6443-5893
Phillips, Rob0000-0003-3082-2809
Kondev, Jane0000-0001-7522-7144
Additional Information:© 2016 Annual Reviews. Review in Advance first posted online on April 29, 2016. We wish to thank the Brandeis Cable Club (Julian Eskin, Sal Alioto, Brian Graziano, Mikael Garabedian) for many stimulating discussions about cytoskeletal length regulation and the biological mechanisms underlying them. Discussions with Wallace Marshall, Stephanie Weber, David Kovar, Fred Chang, and Arjun Raj about general issues regarding organelle size control were also very helpful. This work was supported by the National Science Foundation through grants DMR-1206146 (J.K.) and MRSEC-1420382 (B.L.G. and J.K.); and by the National Institutes of Health grants DP10D000217 (R.P.), R01GM085286 (R.P.), and R01GM083137 (B.L.G.). We are grateful to the Burroughs-Wellcome Fund for its support of the Physiology Course at the Marine Biological Laboratory, where part of the work on this review was done, and for a postcourse research grant (L.M.). The authors are not aware of any affiliations, memberships, funding, or financial holdings that might be perceived as affecting the objectivity of this review.
Funders:
Funding AgencyGrant Number
NSFDMR-1206146
NSFMRSEC-1420382
NIHDP10D000217
NIHR01GM085286
NIHR01GM083137
Burroughs-Wellcome FundUNSPECIFIED
Subject Keywords:organelle size, actin filaments, microtubules, living polymers, master equation
PubMed Central ID:PMC5466818
DOI:10.1146/annurev-biophys-070915-094206
Record Number:CaltechAUTHORS:20160509-153942313
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160509-153942313
Official Citation:Design Principles of Length Control of Cytoskeletal Structures Lishibanya Mohapatra, Bruce L. Goode, Predrag Jelenkovic, Rob Phillips, and Jane Kondev Annual Review of Biophysics, Vol. 45: 85 -116 (Volume publication date July 2016)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66789
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 May 2016 22:52
Last Modified:28 Apr 2022 17:54

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