Renneberg, Dorte and Dervan, Peter B. (2003) Imidazopyridine/Pyrrole and hydroxybenzimidazole/pyrrole pairs for DNA minor groove recognition. Journal of the American Chemical Society, 125 (19). pp. 5707-5716. ISSN 0002-7863. doi:10.1021/ja0300158. https://resolver.caltech.edu/CaltechAUTHORS:20160510-080155936
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Abstract
The DNA binding properties of fused heterocycles imidazo[4,5-b]pyridine (Ip) and hydroxybenzimidazole (Hz) paired with pyrrole (Py) in eight-ring hairpin polyamides are reported. The recognition profile of Ip/Py and Hz/Py pairs were compared to the five-membered ring pairs Im/Py and Hp/Py on a DNA restriction fragment at four 6-base pair recognition sites which vary at a single position 5'-TGTNTA-3', where N = G, C, T, A. The Ip/Py pair distinguishes G.C from C.G, T.A, and A.T, and the Hz/Py pair distinguishes T.A from A.T, G.C, and C.G, affording a new set of heterocycle pairs to target the four Watson-Crick base pairs in the minor groove of DNA.
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| Additional Information: | © 2003 American Chemical Society. Received January 7, 2003. Publication Date (Web): April 16, 2003. We are grateful to the National Institute of Health (GM27681) for research support and the Swiss National Science Foundation for a postdoctoral fellowship to D.R. We thank M. A. Marques for guidance with the ab initio calculations. | ||||||||||||
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| Issue or Number: | 19 | ||||||||||||
| DOI: | 10.1021/ja0300158 | ||||||||||||
| Record Number: | CaltechAUTHORS:20160510-080155936 | ||||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160510-080155936 | ||||||||||||
| Official Citation: | Imidazopyridine/Pyrrole and Hydroxybenzimidazole/Pyrrole Pairs for DNA Minor Groove Recognition Dorte Renneberg and Peter B. Dervan Journal of the American Chemical Society 2003 125 (19), 5707-5716 DOI: 10.1021/ja0300158 | ||||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||||
| ID Code: | 66804 | ||||||||||||
| Collection: | CaltechAUTHORS | ||||||||||||
| Deposited By: | Victoria Brennan | ||||||||||||
| Deposited On: | 18 May 2016 00:34 | ||||||||||||
| Last Modified: | 11 Nov 2021 00:03 |
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