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Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates

Belitsky, Jason M. and Leslie, Stephanie J. and Arora, Paramjit S. and Beerman, Terry A. and Dervan, Peter B. (2002) Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates. Bioorganic and Medicinal Chemistry, 10 (10). pp. 3313-3318. ISSN 0968-0896.

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The cellular uptake and localization properties of DNA binding N-methylpyrrole/N-methylimidazole polyamide-dye conjugates in a variety of living cells have been examined by confocal laser scanning microscopy. With the exception of certain T-cell lines, polyamide-dye conjugates localize mainly in the cytoplasm and not in the nucleus. Reagents such as methanol typically used to fix cells for microscopy significantly alter the cellular localization of these DNA-binding ligands.

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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 2002 Elsevier Science Ltd. Received 5 February 2002; accepted 16 April 2002. We are grateful to Scott Fraser and Hayong Lim for use of the Caltech Biological Imaging Facility and assistance in confocal microscopy. Special thanks to Inder Nangiana of the Caltech Protein Expression Facility for help with cell culture. We are indebted to Aseem Z. Ansari, Joel Pomerantz, Joel Gottesfeld, and Carl Parker for providing cells and helpful suggestions. We are grateful to the National Institutes of Health (GM 51747) for research support, the Ralph M. Parsons Foundation for a predoctoral fellowship to J.M.B., and the American Cancer Society for a post-doctoral fellowship to P.S.A.
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Ralph M. Parsons FoundationUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Issue or Number:10
Record Number:CaltechAUTHORS:20160510-081405436
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Official Citation:Jason M Belitsky, Stephanie J Leslie, Paramjit S Arora, Terry A Beerman, Peter B Dervan, Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates, Bioorganic & Medicinal Chemistry, Volume 10, Issue 10, October 2002, Pages 3313-3318, ISSN 0968-0896, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66815
Deposited By: Victoria Brennan
Deposited On:17 May 2016 17:26
Last Modified:26 Nov 2019 11:15

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