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Chemical approaches to control gene expression

Gottesfeld, J. M. and Turner, J. M. and Dervan, P. B. (2001) Chemical approaches to control gene expression. Gene Expression, 9 (1-2). pp. 77-92. ISSN 1052-2166. https://resolver.caltech.edu/CaltechAUTHORS:20160510-091107844

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Abstract

A current goal in molecular medicine is the development of new strategies to interfere with gene expression in living cells in the hope that novel therapies for human disease will result from these efforts. This review focuses on small-molecule or chemical approaches to manipulate gene expression by modulating either transcription of messenger RNA-coding genes or protein translation. The molecules under study include natural products, designed ligands, and compounds identified through functional screens of combinatorial libraries. The cellular targets for these molecules include DNA, messenger RNA, and the protein components of the transcription, RNA processing, and translational machinery. Studies with model systems have shown promise in the inhibition of both cellular and viral gene transcription and mRNA utilization. Moreover, strategies for both repression and activation of gene transcription have been described. These studies offer promise for treatment of diseases of pathogenic (viral, bacterial, etc.) and cellular origin (cancer, genetic diseases, etc.).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.3727/000000001783992696DOIArticle
http://www.ingentaconnect.com/content/cog/ge/2001/00000009/F0020001/ge151PublisherArticle
ORCID:
AuthorORCID
Dervan, P. B.0000-0001-8852-7306
Additional Information:© 2001 Cognizant Communication Corporation. Publication date: January 1, 2001.
Subject Keywords:Gene transcription; Molecular medicine; Novel therapy
Issue or Number:1-2
Record Number:CaltechAUTHORS:20160510-091107844
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160510-091107844
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66845
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:18 May 2016 20:37
Last Modified:26 Nov 2019 11:15

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