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Sequence-specific DNA recognition by polyamides

Dervan, Peter B. and Bürli, Roland W. (1999) Sequence-specific DNA recognition by polyamides. Current Opinion in Chemical Biology, 3 (6). pp. 688-93. ISSN 1367-5931. doi:10.1016/S1367-5931(99)00027-7.

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Sequence-specific DNA-binding small molecules that can permeate cells could potentially regulate transcription of specific genes. Simple pairing rules for the minor groove of the double helix have been developed that allow the design of ligands for predetermined DNA sequences. Some of these polyamides have been shown to inhibit specific gene expression in mammalian cell culture.

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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1999 Elsevier Science Ltd. The work described in this review from our group was supported by the National Institutes of Health.
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Issue or Number:6
Record Number:CaltechAUTHORS:20160510-091115065
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Official Citation:Peter B Dervan, Roland W Bürli, Sequence-specific DNA recognition by polyamides, Current Opinion in Chemical Biology, Volume 3, Issue 6, 1 December 1999, Pages 688-693, ISSN 1367-5931, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66851
Deposited By: Victoria Brennan
Deposited On:17 May 2016 17:16
Last Modified:11 Nov 2021 00:22

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