Herman, David M. and Baird, Eldon E. and Dervan, Peter B. (1999) Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole–Imidazole Polyamides. Chemistry: a European Journal, 5 (3). pp. 975-983. ISSN 0947-6539. doi:10.1002/(SICI)1521-3765(19990301)5:3<975::AID-CHEM975>3.0.CO;2-T. https://resolver.caltech.edu/CaltechAUTHORS:20160510-092252491
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Abstract
Linking hairpin recognition units “tail-to-turn” in the minor groove of DNA results in the extension of hairpin polyamide binding site size to 11 base pairs. A twelve-ring tandem hairpin (see diagram) binds its match DNA site at picomolar concentrations with unprecedented sequence specificity.
| Item Type: | Article | ||||||||
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| Additional Information: | © 1999 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: August 31, 1998. First published: 24 February 1999. We are grateful to the National Institutes of Health (GM-27681) for research support, the National Institutes of Health for a research service award to D.M.H., and the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. We thank G.M. Hathaway for MALDITOF mass spectrometry. | ||||||||
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| Subject Keywords: | DNA recognition; hydrogen bonds; pairing code; sequence specificity | ||||||||
| Issue or Number: | 3 | ||||||||
| DOI: | 10.1002/(SICI)1521-3765(19990301)5:3<975::AID-CHEM975>3.0.CO;2-T | ||||||||
| Record Number: | CaltechAUTHORS:20160510-092252491 | ||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160510-092252491 | ||||||||
| Official Citation: | Herman, D. M., Baird, E. E. and Dervan, P. B. (1999), Tandem Hairpin Motif for Recognition in the Minor Groove of DNA by Pyrrole–Imidazole Polyamides. Chem. Eur. J., 5: 975–983. doi:10.1002/(SICI)1521-3765(19990301)5:3<975::AID-CHEM975>3.0.CO;2-T | ||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||
| ID Code: | 66854 | ||||||||
| Collection: | CaltechAUTHORS | ||||||||
| Deposited By: | Victoria Brennan | ||||||||
| Deposited On: | 10 May 2016 19:03 | ||||||||
| Last Modified: | 11 Nov 2021 00:23 |
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