A Caltech Library Service

Recognition of 16 base pairs in the minor groove of DNA by a pyrrole-imidazole polyamide dimer

Trauger, John W. and Baird, Eldon E. and Dervan, Peter B. (1998) Recognition of 16 base pairs in the minor groove of DNA by a pyrrole-imidazole polyamide dimer. Journal of the American Chemical Society, 120 (14). pp. 3534-3535. ISSN 0002-7863. doi:10.1021/ja9800378.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Cell-permeable small molecules that bind predetermined DNA sequences with affinities and specificities comparable to those of natural DNA-binding proteins have the potential to regulate the expression of specific genes. Recently, an eight-ring hairpin pyrrole-imidazole (Py-Im) polyamide which binds six base pairs of DNA was shown to inhibit transcription of a specific gene in cell culture. Polyamides recognizing longer DNA sequences should provide more specific biological activity. To specify a single site within the 3 billion base pair human genome, ligands which specifically recognize 15-16 base pairs are necessary. For this reason, recognition of 16 base pairs represents a milestone in the development of chemical approaches to DNA recognition. We examine here the affinity and specificity of a Py-Im polyamide dimer which targets 16 contiguous base pairs in the minor groove of DNA.

Item Type:Article
Related URLs:
URLURL TypeDescription DOIArticle
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1998 American Chemical Society. Received January 5, 1998. Publication Date (Web): March 28, 1998. We are grateful to the National Institutes of Health (Grant GM-51747) for research support, to the National Science Foundation and the Ralph M. Parsons Foundation for predoctoral fellowships to J.W.T., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B.
Funding AgencyGrant Number
NSF Predoctoral FellowshipUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:14
Record Number:CaltechAUTHORS:20160510-093520387
Persistent URL:
Official Citation:Recognition of 16 Base Pairs in the Minor Groove of DNA by a Pyrrole−Imidazole Polyamide Dimer John W. Trauger, Eldon E. Baird, and Peter B. Dervan Journal of the American Chemical Society 1998 120 (14), 3534-3535 DOI: 10.1021/ja9800378
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66862
Deposited By: Victoria Brennan
Deposited On:11 May 2016 00:15
Last Modified:11 Nov 2021 00:23

Repository Staff Only: item control page