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Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides

Trauger, John W. and Baird, Eldon E. and Dervan, Peter B. (1998) Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides. Angewandte Chemie-International Edition In English, 37 (10). pp. 1421-1423. ISSN 0570-0833. doi:10.1002/(SICI)1521-3773(19980605)37:10<1421::AID-ANIE1421>3.0.CO;2-8.

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A doubling of the length of binding site for the same size of ligand is achieved by the title compound by formation of a cooperative hairpin dimer on binding to DNA (depicted schematically below). The binding affinity and selectivity are unaffected by this new binding pattern. Circles represent heterocyclic rings, and diamonds and curved lines represent β-alanine and (R)-2,4-diaminobutyric acid residues, respectively.

Item Type:Article
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URLURL TypeDescription<1421::AID-ANIE1421>3.0.CO;2-8DOIArticle;2-8/abstract?2-8/abstractPublisherArticle
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1998 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: January 8, 1998. We are grateful to the National Institutes of Health for support (GM-27681), to the National Science Foundation and the Ralph M. Parsons Foundation for predoctoral fellowships to J.W.T., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. Supporting information for this article is available on the WWW under or from the author.
Funding AgencyGrant Number
NSF Predoctoral FellowshipUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:cooperative effects; DNA recognition; polyamides
Issue or Number:10
Record Number:CaltechAUTHORS:20160510-093706312
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Official Citation:Trauger, J. W., Baird, E. E. and Dervan, P. B. (1998), Cooperative Hairpin Dimers for Recognition of DNA by Pyrrole–Imidazole Polyamides. Angewandte Chemie International Edition, 37: 1421–1423. doi:10.1002/(SICI)1521-3773(19980605)37:10<1421::AID-ANIE1421>3.0.CO;2-8
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66863
Deposited By: Victoria Brennan
Deposited On:11 May 2016 00:09
Last Modified:11 Nov 2021 00:23

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