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Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides

Trauger, John W. and Baird, Eldon E. and Dervan, Peter B. (1998) Cooperative hairpin dimers for recognition of DNA by pyrrole-imidazole polyamides. Angewandte Chemie-International Edition In English, 37 (10). pp. 1421-1423. ISSN 0570-0833. https://resolver.caltech.edu/CaltechAUTHORS:20160510-093706312

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Abstract

A doubling of the length of binding site for the same size of ligand is achieved by the title compound by formation of a cooperative hairpin dimer on binding to DNA (depicted schematically below). The binding affinity and selectivity are unaffected by this new binding pattern. Circles represent heterocyclic rings, and diamonds and curved lines represent β-alanine and (R)-2,4-diaminobutyric acid residues, respectively.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/(SICI)1521-3773(19980605)37:10<1421::AID-ANIE1421>3.0.CO;2-8DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-3773(19980605)37:10%3C1421::AID-ANIE1421%3E3.0.CO;2-8/abstract?2-8/abstractPublisherArticle
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1998 Wiley-VCH Verlag GmbH, D-69451 Weinheim. Received: January 8, 1998. We are grateful to the National Institutes of Health for support (GM-27681), to the National Science Foundation and the Ralph M. Parsons Foundation for predoctoral fellowships to J.W.T., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/home/angewandte/ or from the author.
Funders:
Funding AgencyGrant Number
NIHGM-27681
NSF Predoctoral FellowshipUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:cooperative effects; DNA recognition; polyamides
Issue or Number:10
Record Number:CaltechAUTHORS:20160510-093706312
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160510-093706312
Official Citation:Trauger, J. W., Baird, E. E. and Dervan, P. B. (1998), Cooperative Hairpin Dimers for Recognition of DNA by Pyrrole–Imidazole Polyamides. Angewandte Chemie International Edition, 37: 1421–1423. doi:10.1002/(SICI)1521-3773(19980605)37:10<1421::AID-ANIE1421>3.0.CO;2-8
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66863
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:11 May 2016 00:09
Last Modified:26 Nov 2019 11:15

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