Published May 15, 1998
| Version public
Journal Article
A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA
Abstract
Solid-phase polyamide synthesis is extended to the H-pin motif using a Boc-protected bispyrrole monomer and bidirectional synthesis. Sequence-specific recognition of a designated seven base pair target site is achieved by the formation of a 10-ring H-pin polyamide⋅DNA complex in the minor groove. DNA binding properties are compared with the corresponding hairpin polyamides (see below).
Additional Information
© 1998 Wiley-VCH Verlag GmbH. Received: November 20, 1997; First published: 15 May 1998. We are grateful to the National Institutes of Health (GM-27681) for support of the research and a research traineeship award (GM-08501) for W.A.G., to the Ralph M. Parsons Foundation for a predoctoral fellowship to W.A.G., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B.Additional details
Identifiers
- Eprint ID
- 66864
- DOI
- 10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G
- Resolver ID
- CaltechAUTHORS:20160510-094021673
Related works
- Describes
- 10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G (DOI)
Funding
- NIH
- GM-27681
- NIH Predoctoral Fellowship
- GM-08501
- Ralph M. Parsons Foundation
- Howard Hughes Medical Institute (HHMI)
Dates
- Created
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2016-05-18Created from EPrint's datestamp field
- Updated
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2021-11-11Created from EPrint's last_modified field