Greenberg, William A. and Baird, Eldon E. and Dervan, Peter B. (1998) A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA. Chemistry: a European Journal, 4 (5). pp. 796-805. ISSN 0947-6539. doi:10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G. https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673
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Abstract
Solid-phase polyamide synthesis is extended to the H-pin motif using a Boc-protected bispyrrole monomer and bidirectional synthesis. Sequence-specific recognition of a designated seven base pair target site is achieved by the formation of a 10-ring H-pin polyamide⋅DNA complex in the minor groove. DNA binding properties are compared with the corresponding hairpin polyamides (see below).
Item Type: | Article | ||||||||||
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Additional Information: | © 1998 Wiley-VCH Verlag GmbH. Received: November 20, 1997; First published: 15 May 1998. We are grateful to the National Institutes of Health (GM-27681) for support of the research and a research traineeship award (GM-08501) for W.A.G., to the Ralph M. Parsons Foundation for a predoctoral fellowship to W.A.G., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B. | ||||||||||
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Subject Keywords: | binding affinity; hydrogen bonds; molecular recognition; solid-phase synthesis; DNA recognition | ||||||||||
Issue or Number: | 5 | ||||||||||
DOI: | 10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G | ||||||||||
Record Number: | CaltechAUTHORS:20160510-094021673 | ||||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673 | ||||||||||
Official Citation: | Greenberg, W. A., Baird, E. E. and Dervan, P. B. (1998), A Comparison of H-Pin and Hairpin Polyamide Motifs for the Recognition of the Minor Groove of DNA. Chem. Eur. J., 4: 796–805. doi:10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G | ||||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
ID Code: | 66864 | ||||||||||
Collection: | CaltechAUTHORS | ||||||||||
Deposited By: | Victoria Brennan | ||||||||||
Deposited On: | 18 May 2016 21:10 | ||||||||||
Last Modified: | 11 Nov 2021 00:23 |
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