A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA

Greenberg, William A. and Baird, Eldon E. and Dervan, Peter B. (1998) A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA. Chemistry: a European Journal, 4 (5). pp. 796-805. ISSN 0947-6539. doi:10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G. https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673

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Abstract

Solid-phase polyamide synthesis is extended to the H-pin motif using a Boc-protected bispyrrole monomer and bidirectional synthesis. Sequence-specific recognition of a designated seven base pair target site is achieved by the formation of a 10-ring H-pin polyamide⋅DNA complex in the minor groove. DNA binding properties are compared with the corresponding hairpin polyamides (see below).

Item Type:

Article

Related URLs:

URL	URL Type	Description
http://dx.doi.org/10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G	DOI	Article
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-3765(19980515)4:5%3C796::AID-CHEM796%3E3.0.CO;2-G/abstract?2-G/abstract	Publisher	Article

ORCID:

Author	ORCID
Dervan, Peter B.	0000-0001-8852-7306

Additional Information:

© 1998 Wiley-VCH Verlag GmbH. Received: November 20, 1997; First published: 15 May 1998. We are grateful to the National Institutes of Health (GM-27681) for support of the research and a research traineeship award (GM-08501) for W.A.G., to the Ralph M. Parsons Foundation for a predoctoral fellowship to W.A.G., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B.

Funders:

Funding Agency	Grant Number
NIH	GM-27681
NIH Predoctoral Fellowship	GM-08501
Ralph M. Parsons Foundation	UNSPECIFIED
Howard Hughes Medical Institute (HHMI)	UNSPECIFIED

Subject Keywords:

binding affinity; hydrogen bonds; molecular recognition; solid-phase synthesis; DNA recognition

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DOI:

10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G

Record Number:

CaltechAUTHORS:20160510-094021673

Persistent URL:

https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673

Official Citation:

Greenberg, W. A., Baird, E. E. and Dervan, P. B. (1998), A Comparison of H-Pin and Hairpin Polyamide Motifs for the Recognition of the Minor Groove of DNA. Chem. Eur. J., 4: 796–805. doi:10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G

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ID Code:

66864

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CaltechAUTHORS

Deposited By:

Victoria Brennan

Deposited On:

18 May 2016 21:10

Last Modified:

11 Nov 2021 00:23

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