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A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA

Greenberg, William A. and Baird, Eldon E. and Dervan, Peter B. (1998) A comparison of H-pin and hairpin polyamide motifs for the recognition of the minor groove of DNA. Chemistry: a European Journal, 4 (5). pp. 796-805. ISSN 0947-6539. https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673

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Abstract

Solid-phase polyamide synthesis is extended to the H-pin motif using a Boc-protected bispyrrole monomer and bidirectional synthesis. Sequence-specific recognition of a designated seven base pair target site is achieved by the formation of a 10-ring H-pin polyamide⋅DNA complex in the minor groove. DNA binding properties are compared with the corresponding hairpin polyamides (see below).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-3765(19980515)4:5%3C796::AID-CHEM796%3E3.0.CO;2-G/abstract?2-G/abstractPublisherArticle
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1998 Wiley-VCH Verlag GmbH. Received: November 20, 1997; First published: 15 May 1998. We are grateful to the National Institutes of Health (GM-27681) for support of the research and a research traineeship award (GM-08501) for W.A.G., to the Ralph M. Parsons Foundation for a predoctoral fellowship to W.A.G., and to the Howard Hughes Medical Institute for a predoctoral fellowship to E.E.B.
Funders:
Funding AgencyGrant Number
NIHGM-27681
NIH Predoctoral FellowshipGM-08501
Ralph M. Parsons FoundationUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:binding affinity; hydrogen bonds; molecular recognition; solid-phase synthesis; DNA recognition
Issue or Number:5
Record Number:CaltechAUTHORS:20160510-094021673
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160510-094021673
Official Citation:Greenberg, W. A., Baird, E. E. and Dervan, P. B. (1998), A Comparison of H-Pin and Hairpin Polyamide Motifs for the Recognition of the Minor Groove of DNA. Chem. Eur. J., 4: 796–805. doi:10.1002/(SICI)1521-3765(19980515)4:5<796::AID-CHEM796>3.0.CO;2-G
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66864
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:18 May 2016 21:10
Last Modified:26 Nov 2019 11:15

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