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Targeting the minor groove of DNA

Wemmer, David E. and Dervan, Peter B. (1997) Targeting the minor groove of DNA. Current Opinion in Structural Biology, 7 (3). pp. 355-361. ISSN 0959-440X. doi:10.1016/S0959-440X(97)80051-6.

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Small molecules that specifically bind with high affinity to any predetermined DNA sequence in the human genome will be useful tools in molecular biology and, potentially, in human medicine. Pairing rules have been developed to control rationally the sequence specificity of minor groove binding polyamides containing N-methylimidazole and N-methylpyrrole amino acids. Using simple molecular shapes and a two-letter aromatic amino acid code, pyrrole-imidazole polyamides achieve affinities and specificities comparable to DNA-binding proteins.

Item Type:Article
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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1997 Current Biology Ltd.
Issue or Number:3
Record Number:CaltechAUTHORS:20160510-102058643
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Official Citation:David E Wemmer, Peter B Dervan, Targeting the minor groove of DNA, Current Opinion in Structural Biology, Volume 7, Issue 3, June 1997, Pages 355-361, ISSN 0959-440X, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66879
Deposited By: Victoria Brennan
Deposited On:17 May 2016 23:11
Last Modified:11 Nov 2021 00:23

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