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Sequence-specific recognition of DNA by a major and minor groove binding ligand

Szewczyk, Jason W. and Baird, Eldon E. and Dervan, Peter B. (1996) Sequence-specific recognition of DNA by a major and minor groove binding ligand. Angewandte Chemie International Edition, 35 (13-14). pp. 1487-1489. ISSN 1433-7851. https://resolver.caltech.edu/CaltechAUTHORS:20160510-102930862

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Abstract

A combination of the binding models for the simultaneous recognition of both grooves of DNA led to the design of a polyamide–oligonucleotide ligand that binds to a specific DNA sequence with an association constant of K_a > 2 × 10^(10) M^(−1). The oligonucleotide portion forms a triple helix in the major groove of DNA, and the polyamide unit forms a hairpin in the minor groove (see ribbon model below).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1002/anie.199614871DOIArticle
http://onlinelibrary.wiley.com/doi/10.1002/anie.199614871/fullPublisherArticle
Additional Information:© 1996 VCH Verlagsgesellschuft mbH. Received: March 3. 1996. We are grateful to the National Institutes of Health for support (GM-27681) and to the Howard Hughes Medical Institute for a Predoctoral Fellowship to E. E. B.
Funders:
Funding AgencyGrant Number
NIHGM-27681
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:DNA; polyamides; triple helices
Issue or Number:13-14
Record Number:CaltechAUTHORS:20160510-102930862
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160510-102930862
Official Citation:Szewczyk, J. W., Baird, E. E. and Dervan, P. B. (1996), Sequence-Specific Recognition of DNA by a Major and Minor Groove Binding Ligand. Angew. Chem. Int. Ed. Engl., 35: 1487–1489. doi:10.1002/anie.199614871
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66885
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:18 May 2016 22:24
Last Modified:03 Oct 2019 10:01

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