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Effects of an abasic site on triple helix formation characterized by affinity cleaving

Horne, David A. and Dervan, Peter B. (1991) Effects of an abasic site on triple helix formation characterized by affinity cleaving. Nucleic Acids Research, 19 (18). pp. 4963-4965. ISSN 0305-1048. PMCID PMC328797. https://resolver.caltech.edu/CaltechAUTHORS:20160510-145811847

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Abstract

The stability of triple helical complexes of pyrimidine oligodeoxyribonucleotides containing one abasic 1,2- dideoxy-D-ribose (ø) residue was examined by affinity cleaving. Within a pyrimidine third strand, the triplets ø·AT, ø·GC, ø·TA and ø·CG are significantly less stable than the triplets, T- AT, C + GC and GTA. The decrease in binding produced by an abasic residue is similar to that observed with imperfectly matched natural base triplets, with ø · AT and ø · GC being less stable than ø · TA and ø · CG triplets for the sequences studied.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1093/nar/19.18.4963DOIArticle
http://nar.oxfordjournals.org/content/19/18/4963PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC328797/PubMed CentralArticle
Additional Information:© 1991 Oxford University Press. Received June 7, 1991; Revised and Accepted August 9, 1991. We are grateful for grant support from the National Institutes of Health, the Office of Naval Research, an unrestricted research grant from Burroughs-Wellcome, and a National Institutes of Health postdoctoral fellowship from the National Institutes of General Medical Science (D.A.H.).
Funders:
Funding AgencyGrant Number
Office of Naval Research (ONR)UNSPECIFIED
Burroughs-WellcomeUNSPECIFIED
NIH Postdoctoral FellowshipUNSPECIFIED
Issue or Number:18
PubMed Central ID:PMC328797
Record Number:CaltechAUTHORS:20160510-145811847
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160510-145811847
Official Citation:David A. Horne and Peter B. Dervan Effects of an abasic site on triple helix formation characterized by affinity cleaving Nucl. Acids Res. (1991) 19 (18): 4963-4965 doi:10.1093/nar/19.18.4963
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66954
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 18:35
Last Modified:03 Oct 2019 10:01

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