Luebke, Kevin J. and Dervan, Peter B. (1989) Nonenzymatic ligation of oligodeoxyribonucleotides on a duplex DNA template by triple-helix formation. Journal of the American Chemical Society, 111 (23). pp. 8733-8735. ISSN 0002-7863. doi:10.1021/ja00205a033. https://resolver.caltech.edu/CaltechAUTHORS:20160510-152740060
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Abstract
We report that a double-stranded DNA template can direct the sequence-specific formation of a phosphodiester linkage between oligodeoxyribonucleotides in aqueous solution by juxtaposing the termini head-to-tail in a triple-helical complex (Figure 1). A triple-stranded complex can be formed when a pyrimidine oligodeoxynucleotide binds in the major groove of duplex DNA parallel to the purine Watson-Crick strand. In the complex, sequence specificity for the condensation of oligodeoxynucleotides is directed by Hoogsteen base pairing.
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| Additional Information: | © 1989 American Chemical Society. Received August 2, 1989. This work was supported in part by the National Institutes of Health (GM-35724) and the Caltech Consortium in Chemistry and Chemical Engineering (founding members: E. I. du Pont de Nemours and Company, Inc., Eastman Kodak Company, Minnesota Mining and Manufacturing Company, and Shell Oil Company Foundation). We are grateful for a National Research Service Award to K.J.L. from the National Institute of General Medical Science. | |||||||||
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| Issue or Number: | 23 | |||||||||
| DOI: | 10.1021/ja00205a033 | |||||||||
| Record Number: | CaltechAUTHORS:20160510-152740060 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160510-152740060 | |||||||||
| Official Citation: | Nonenzymatic ligation of oligodeoxyribonucleotides on a duplex DNA template by triple-helix formation Kevin J. Luebke and Peter B. Dervan Journal of the American Chemical Society 1989 111 (23), 8733-8735 DOI: 10.1021/ja00205a033 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 66961 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 19 May 2016 18:46 | |||||||||
| Last Modified: | 11 Nov 2021 00:24 |
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