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Cooperative site specific binding of oligonucleotides to duplex DNA

Strobel, Scott A. and Dervan, Peter B. (1989) Cooperative site specific binding of oligonucleotides to duplex DNA. Journal of the American Chemical Society, 111 (18). pp. 7286-7287. ISSN 0002-7863. doi:10.1021/ja00200a073.

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Cooperative interactions between DNA binding ligands are critical to their specificity, affinity, and biological activity. Triple helix formation by oligonucleotides is the most powerful chemical approach to date for the sequence-specific recognition of double helical DNA. Hoogsteen hydrogen bonded base triplets, TAT and C+GC, result from pyrimidine oligonucleotides binding site specifically to purine duplex sequences. In the triple helical model, a binding site size of 18 purine base pairs affords 36 discrete sequence-specific hydrogen bonds for recognition of DNA in the major groove. As a possible mechanism for improving the specificity of triple helix formation, we tested whether oligonucleotides could cooperatively bind to a double-stranded DNA template.

Item Type:Article
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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1989 American Chemical Society. Received March 20, 1989. Acknowledgment. This work was supported in part by the National Institutes of Health (GM-35724) and the Caltech Consortium in Chemistry and Chemical Engineering (Founding members: E. I. du Pont de Nemours & Co., Inc., Eastman Kodak Company, Minnesota Mining and Manufacturing Company, and Shell Oil Company Foundation).
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Caltech Consortium in Chemistry and Chemical EngineeringUNSPECIFIED
Issue or Number:18
Record Number:CaltechAUTHORS:20160510-155444926
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Official Citation:Cooperative site specific binding of oligonucleotides to duplex DNA Scott A. Strobel and Peter B. Dervan Journal of the American Chemical Society 1989 111 (18), 7286-7287 DOI: 10.1021/ja00200a073
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66962
Deposited By: Victoria Brennan
Deposited On:19 May 2016 19:07
Last Modified:11 Nov 2021 00:24

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