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Triple helix formation by oligonucleotides on DNA extended to the physiological pH range

Povsic, Thomas J. and Dervan, Peter B. (1989) Triple helix formation by oligonucleotides on DNA extended to the physiological pH range. Journal of the American Chemical Society, 111 (8). pp. 3059-3061. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160510-160429152

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Abstract

We report here that oligodeoxyribonucleotides which contain 5-bromouracil (Br^5U) and 5-methylcytosine (m^5C) bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range. Oligonucleotides containing uracil (U) bind with lower affinity (Figure 1).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00190a047DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00190a047PublisherArticle
Additional Information:© 1989 American Chemical Society. Received September 16, 1988. We are grateful to the National Institutes of Health (GM 35724), Office of Naval Research for grant support (Contract N00014-88-K-0441) and to the National Science Foundation for a predoctoral fellowship to T.J.P.
Funders:
Funding AgencyGrant Number
NIHGM-35724
Office of Naval Research (ONR)N00014-88-K-0441
NSF Predoctoral FellowshipUNSPECIFIED
Record Number:CaltechAUTHORS:20160510-160429152
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160510-160429152
Official Citation:Triple helix formation by oligonucleotides on DNA extended to the physiological pH range Thomas J. Povsic and Peter B. Dervan Journal of the American Chemical Society 1989 111 (8), 3059-3061 DOI: 10.1021/ja00190a047
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:66968
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 19:19
Last Modified:19 May 2016 19:19

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