Povsic, Thomas J. and Dervan, Peter B. (1989) Triple helix formation by oligonucleotides on DNA extended to the physiological pH range. Journal of the American Chemical Society, 111 (8). pp. 3059-3061. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160510-160429152
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Abstract
We report here that oligodeoxyribonucleotides which contain 5-bromouracil (Br^5U) and 5-methylcytosine (m^5C) bind duplex DNA at the same homopurine target sequence as their T/C analogues but with greater affinities and over an extended pH range. Oligonucleotides containing uracil (U) bind with lower affinity (Figure 1).
| Item Type: | Article | |||||||||
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| Additional Information: | © 1989 American Chemical Society. Received September 16, 1988. We are grateful to the National Institutes of Health (GM 35724), Office of Naval Research for grant support (Contract N00014-88-K-0441) and to the National Science Foundation for a predoctoral fellowship to T.J.P. | |||||||||
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| Record Number: | CaltechAUTHORS:20160510-160429152 | |||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20160510-160429152 | |||||||||
| Official Citation: | Triple helix formation by oligonucleotides on DNA extended to the physiological pH range Thomas J. Povsic and Peter B. Dervan Journal of the American Chemical Society 1989 111 (8), 3059-3061 DOI: 10.1021/ja00190a047 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 66968 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 19 May 2016 19:19 | |||||||||
| Last Modified: | 19 May 2016 19:19 |
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