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Metalloregulation in the sequence specific binding of synthetic molecules to DNA

Griffin, John H. and Dervan, Peter B. (1987) Metalloregulation in the sequence specific binding of synthetic molecules to DNA. Journal of the American Chemical Society, 109 (22). pp. 6840-6842. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20160511-144439605

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Abstract

Specific metal cations exert remarkable effects on the transcription of several prokaryotic and eukaryotic genes. Recently, the DNA-binding eukaryotic transcription factor TFIIIA has been characterized as a series of peptide fingers connected by zinc-binding domains. These observations raise the issue of whether the binding of synthetic molecules to DNA could in some way be regulated by the addition of specific metal ions.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00256a043DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00256a043PublisherArticle
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1987 American Chemical Society. Received April 10, 1987. We are grateful to the National Institutes of Health for research support (GM 27681} and to the National Science Foundation for a predoctoral fellowship to J.H.G.
Funders:
Funding AgencyGrant Number
NIHGM-27681
NSF Predoctoral FellowshipUNSPECIFIED
Issue or Number:22
Record Number:CaltechAUTHORS:20160511-144439605
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160511-144439605
Official Citation:Metalloregulation in the sequence specific binding of synthetic molecules to DNA John H. Griffin and Peter B. Dervan Journal of the American Chemical Society 1987 109 (22), 6840-6842 DOI: 10.1021/ja00256a043
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67010
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 19:36
Last Modified:26 Nov 2019 11:15

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