Baker, Brenda F. and Dervan, Peter B. (1985) Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin. Journal of the American Chemical Society, 107 (26). pp. 8266-8268. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160511-151543575
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Abstract
We report that N-bromoacetyldistamcyin (BD) which contains the electrophile bromoacetyl on the amino end of the tripeptide tris-N-methylpyrrolecarboxamide" cleaves a single adenine within a restriction fragment containing 167 base pairs of DNA after 5 h of reaction time at 37 °C followed by a depurination workup procedure.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1985 American Chemical Society. Received July 19, 1985. We are grateful to the National Institutes of Health (GM-27681) for support of this research. | |||||||||
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| Record Number: | CaltechAUTHORS:20160511-151543575 | |||||||||
| Persistent URL: | http://resolver.caltech.edu/CaltechAUTHORS:20160511-151543575 | |||||||||
| Official Citation: | Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin Brenda F. Baker and Peter B. Dervan Journal of the American Chemical Society 1985 107 (26), 8266-8268 DOI: 10.1021/ja00312a079 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 67018 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 19 May 2016 20:33 | |||||||||
| Last Modified: | 19 May 2016 20:33 |
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