CaltechAUTHORS
  A Caltech Library Service

Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin

Baker, Brenda F. and Dervan, Peter B. (1985) Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin. Journal of the American Chemical Society, 107 (26). pp. 8266-8268. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160511-151543575

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: http://resolver.caltech.edu/CaltechAUTHORS:20160511-151543575

Abstract

We report that N-bromoacetyldistamcyin (BD) which contains the electrophile bromoacetyl on the amino end of the tripeptide tris-N-methylpyrrolecarboxamide" cleaves a single adenine within a restriction fragment containing 167 base pairs of DNA after 5 h of reaction time at 37 °C followed by a depurination workup procedure.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00312a079DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00312a079PublisherArticle
Additional Information:© 1985 American Chemical Society. Received July 19, 1985. We are grateful to the National Institutes of Health (GM-27681) for support of this research.
Funders:
Funding AgencyGrant Number
NIHGM-27681
Record Number:CaltechAUTHORS:20160511-151543575
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160511-151543575
Official Citation:Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin Brenda F. Baker and Peter B. Dervan Journal of the American Chemical Society 1985 107 (26), 8266-8268 DOI: 10.1021/ja00312a079
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67018
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 20:33
Last Modified:19 May 2016 20:33

Repository Staff Only: item control page