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Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin

Baker, Brenda F. and Dervan, Peter B. (1985) Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin. Journal of the American Chemical Society, 107 (26). pp. 8266-8268. ISSN 0002-7863. doi:10.1021/ja00312a079.

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We report that N-bromoacetyldistamcyin (BD) which contains the electrophile bromoacetyl on the amino end of the tripeptide tris-N-methylpyrrolecarboxamide" cleaves a single adenine within a restriction fragment containing 167 base pairs of DNA after 5 h of reaction time at 37 °C followed by a depurination workup procedure.

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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1985 American Chemical Society. Received July 19, 1985. We are grateful to the National Institutes of Health (GM-27681) for support of this research.
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Issue or Number:26
Record Number:CaltechAUTHORS:20160511-151543575
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Official Citation:Sequence-specific cleavage of double-helical DNA. N-Bromoacetyldistamycin Brenda F. Baker and Peter B. Dervan Journal of the American Chemical Society 1985 107 (26), 8266-8268 DOI: 10.1021/ja00312a079
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67018
Deposited By: Victoria Brennan
Deposited On:19 May 2016 20:33
Last Modified:11 Nov 2021 00:25

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