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Sequence-specific recognition of B DNA by bis(EDTA-distamycin)fumaramide

Youngquist, R. Scott and Dervan, Peter B. (1985) Sequence-specific recognition of B DNA by bis(EDTA-distamycin)fumaramide. Journal of the American Chemical Society, 107 (19). pp. 5528-5529. ISSN 0002-7863. doi:10.1021/ja00305a036.

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We report a new sequence-specific DNA binding molecule, bis(EDTA-distamycin)fumaramide (BEDF)8 (Figure 2). This crescent-shaped octaamide contains two N-methylpyrrole tripeptide units’-6 coupled at the amino termini via fumaric acid (Figure 2). Attachment of EDTA to the carboxy terminus of each tripeptide allows use of the affinity cleaving methodM to visualize the sequence and size of the DNA recognition site by analysis of DNA cleavage patterns on 32P-end-labeled DNA restriction fragments by high-resolution denaturing gel electrophoreses.

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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1985 American Chemical Society. Received March 18, 1985. We are grateful to the National Institutes of Health for grant support (GM-27681).
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Issue or Number:19
Record Number:CaltechAUTHORS:20160511-151714373
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Official Citation:Sequence-specific recognition of B DNA by bis(EDTA-distamycin)fumaramide R. Scott Youngquist and Peter B. Dervan Journal of the American Chemical Society 1985 107 (19), 5528-5529 DOI: 10.1021/ja00305a036
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67019
Deposited By: Victoria Brennan
Deposited On:19 May 2016 20:36
Last Modified:11 Nov 2021 00:25

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