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Comparison of synthetic psoralen derivatives and 8-MOP in the inhibition of lymphocyte proliferation

Berger, Carole L. and Cantor, Charles and Welsh, John and Dervan, Peter and Begley, Tadng and Grant, Steven and Gasparro, Francis P. and Edelson, Richard L. (1985) Comparison of synthetic psoralen derivatives and 8-MOP in the inhibition of lymphocyte proliferation. Annals of the New York Academy of Sciences, 453 . pp. 80-90. ISSN 0077-8923. doi:10.1111/j.1749-6632.1985.tb11800.x.

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Psoralens are a family of furocoumarins that naturally occur in nature in small amounts in a variety of common vegetables, including figs and limes, and in larger quantities in plants originally identified in the Nile valley and in India.' These molecules have the remarkable quality of being activated by ultraviolet A (UVA) from a biologically inert form to one capable of forming covalent bonds with the pyrimidine bases of DNA.

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Dervan, Peter0000-0001-8852-7306
Grant, Steven0000-0003-0923-8886
Additional Information:© 1985 New York Academy of Sciences. This research was supported by NIH Grants RR00645, CA20499, and GM14825. The authors wish to acknowledge the excellent secretarial assistance of Ms. Betty Carroll.
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Official Citation:BERGER, C. L., CANTOR, C., WELSH, J., DERVAN, P., BEGLEY, T., GRANT, S., GASPARRO, F. P. and EDELSON, R. L. (1985), Comparison of Synthetic Psoralen Derivatives and 8-MOP in the Inhibition of Lymphocyte Proliferation. Annals of the New York Academy of Sciences, 453: 80–90. doi: 10.1111/j.1749-6632.1985.tb11800.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67025
Deposited By: Victoria Brennan
Deposited On:19 May 2016 22:50
Last Modified:11 Nov 2021 00:25

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