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Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid

Mitchell, Mark A. and Dervan, Peter B. (1982) Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid. Journal of the American Chemical Society, 104 (15). pp. 4265-4266. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160511-154312167

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Abstract

We describe the synthesis and purification of a new light-sensitive bifunctional molecule, bis(monoazidomethidium)octaoxahexacosanediamine (BAMO) (1), which contains all the criteria presumed necessary for an interhelical DNA-DNA cross-linker: a photoreactive DNA intercalator, monoazidomethidium, and a polyethyleneoxy chain sufficiently long (>25 Å) to span contiguous nucleic acid double helices. We also present evidence that BAMO efficiently cross-links packaged nucleic acid in intact bacteriophage λ.


Item Type:Article
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http://dx.doi.org/10.1021/ja00379a045DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00379a045PublisherArticle
Additional Information:© 1982 American Chemical Society. Received March 10, 1982. We are grateful to the National Institutes of Health (GM 22909) for generous support and to Professor Charles Cantor, Columbia University, for helpful discussions. Contribution No. 6584 from the Division of Chemistry and Chemical Engineering, California Institute of Technology Pasadena, California 91125.
Funders:
Funding AgencyGrant Number
NIHGM-22909
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Other Numbering System NameOther Numbering System ID
Division of Chemistry and Chemical Engineering6584
Record Number:CaltechAUTHORS:20160511-154312167
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160511-154312167
Official Citation: Interhelical DNA-DNA crosslinking. Bis(monoazidomethidium)octaoxahexacosanediamine: a probe of packaged nucleic acid Mark A. Mitchell and Peter B. Dervan Journal of the American Chemical Society 1982 104 (15), 4265-4266 DOI: 10.1021/ja00379a045
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67032
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 21:44
Last Modified:19 May 2016 21:44

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