Hertzberg, Robert P. and Dervan, Peter B. (1982) Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II). Journal of the American Chemical Society, 104 (1). pp. 313-315. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20160511-154909477
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Abstract
We report the synthesis of a simple bifunctional molecule, methidiumpropyl-EDTA (MPE) (1), which contains the DNA intercalator methidium covalently bound by a short hydrocarbon tether to the metal chelator EDT A. In the presence of ferrous ion and oxygen this reagent efficiently produces single-strand breaks and some double-strand breaks in double helical DNA.
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| Additional Information: | © 1982 American Chemical Society. Received September 28, 1981. We are grateful to the National Institutes of Health for grant support (GM27681) and a National Research Service Award (GM 07616) to R.P.H. Contribution No. 6538 from Division of Chemistry and Chemical Engineering California Institute of Technology, Pasadena, California 91125. | |||||||||
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| Issue or Number: | 1 | |||||||||
| Record Number: | CaltechAUTHORS:20160511-154909477 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160511-154909477 | |||||||||
| Official Citation: | Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II) Robert P. Hertzberg and Peter B. Dervan Journal of the American Chemical Society 1982 104 (1), 313-315 DOI: 10.1021/ja00365a069 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 67034 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 19 May 2016 22:32 | |||||||||
| Last Modified: | 26 Nov 2019 11:15 |
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