A Caltech Library Service

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

Hertzberg, Robert P. and Dervan, Peter B. (1982) Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II). Journal of the American Chemical Society, 104 (1). pp. 313-315. ISSN 0002-7863. doi:10.1021/ja00365a069.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


We report the synthesis of a simple bifunctional molecule, methidiumpropyl-EDTA (MPE) (1), which contains the DNA intercalator methidium covalently bound by a short hydrocarbon tether to the metal chelator EDT A. In the presence of ferrous ion and oxygen this reagent efficiently produces single-strand breaks and some double-strand breaks in double helical DNA.

Item Type:Article
Related URLs:
URLURL TypeDescription
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1982 American Chemical Society. Received September 28, 1981. We are grateful to the National Institutes of Health for grant support (GM27681) and a National Research Service Award (GM 07616) to R.P.H. Contribution No. 6538 from Division of Chemistry and Chemical Engineering California Institute of Technology, Pasadena, California 91125.
Funding AgencyGrant Number
NIH Predoctoral FellowshipGM-07616
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Division of Chemistry and Chemical Engineering6358
Issue or Number:1
Record Number:CaltechAUTHORS:20160511-154909477
Persistent URL:
Official Citation:Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II) Robert P. Hertzberg and Peter B. Dervan Journal of the American Chemical Society 1982 104 (1), 313-315 DOI: 10.1021/ja00365a069
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67034
Deposited By: Victoria Brennan
Deposited On:19 May 2016 22:32
Last Modified:11 Nov 2021 00:26

Repository Staff Only: item control page