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Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

Hertzberg, Robert P. and Dervan, Peter B. (1982) Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II). Journal of the American Chemical Society, 104 (1). pp. 313-315. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160511-154909477

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Abstract

We report the synthesis of a simple bifunctional molecule, methidiumpropyl-EDTA (MPE) (1), which contains the DNA intercalator methidium covalently bound by a short hydrocarbon tether to the metal chelator EDT A. In the presence of ferrous ion and oxygen this reagent efficiently produces single-strand breaks and some double-strand breaks in double helical DNA.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00365a069DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00365a069PublisherArticle
Additional Information:© 1982 American Chemical Society. Received September 28, 1981. We are grateful to the National Institutes of Health for grant support (GM27681) and a National Research Service Award (GM 07616) to R.P.H. Contribution No. 6538 from Division of Chemistry and Chemical Engineering California Institute of Technology, Pasadena, California 91125.
Funders:
Funding AgencyGrant Number
NIHGM-27681
NIH Predoctoral FellowshipGM-07616
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Division of Chemistry and Chemical Engineering6358
Record Number:CaltechAUTHORS:20160511-154909477
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160511-154909477
Official Citation:Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II) Robert P. Hertzberg and Peter B. Dervan Journal of the American Chemical Society 1982 104 (1), 313-315 DOI: 10.1021/ja00365a069
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67034
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:19 May 2016 22:32
Last Modified:19 May 2016 22:32

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