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Metals and DNA: molecular left-handed complements

Barton, Jacqueline K. (1986) Metals and DNA: molecular left-handed complements. Science, 233 (4765). pp. 727-734. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20160513-113952809

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Abstract

Chiral metal complexes provide unique molecular probes for DNA. Chiral reagents that "recognize" different local structures along the DNA strand have been designed by a process in which the asymmetry in shape and size of the complex is matched to that of the DNA helical groove. As a result, the chiral metal complexes provide very sensitive probes for local helical structure, both left- and right-handed. Direct coordination of chiral complexes to the DNA bases adds an element of sequence selectivity to the probe design. With a suitable reactive metal center, reagents that target chemically specific sites along the strand may be developed. One such chiral reagent, which cleaves left-handed DNA sites with photoactivation, has been useful in mapping this distinct conformation and examining its biological role. The conformation-specific molecular cleaver, much like a DNA-binding enzyme, recognizes and reacts at discrete sites along the DNA strand. These site-specific chiral metal complexes provide exciting new tools for probing the local variations in DNA structure and its role in the regulation of gene expression.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.3016894DOIArticle
http://science.sciencemag.org/content/233/4765/727PublisherArticle
ORCID:
AuthorORCID
Barton, Jacqueline K.0000-0001-9883-1600
Additional Information:© 1986 American Association for the Advancement of Science. I am grateful to my co-workers and collaborators, most of whom are named in the accompanying references. Supported by the National Institutes of Health (GM33309) and the National Science Foundation [an Alan T. Waterman award (CHE-8517354) and PYI award (CHE-8351017)].
Funders:
Funding AgencyGrant Number
NIHGM33309
NSFCHE-8517354
NSFCHE-8351017
Issue or Number:4765
Record Number:CaltechAUTHORS:20160513-113952809
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160513-113952809
Official Citation:Metals and DNA: molecular left-handed complements JK Barton Science 15 Aug 1986: Vol. 233, Issue 4765, pp. 727-734 DOI: 10.1126/science.3016894
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67077
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 May 2016 18:50
Last Modified:03 Oct 2019 10:02

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