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Lineage-specific Gene Expression in the Sea Urchin Embryo

Davidson, E. H. and Flytzanis, C. N. and Lee, J. J. and Robinson, J. J. and Rose, S. J., III and Sucov, H. M. (1985) Lineage-specific Gene Expression in the Sea Urchin Embryo. Cold Spring Harbor Symposia on Quantitative Biology, 50 . pp. 321-328. ISSN 0091-7451. https://resolver.caltech.edu/CaltechAUTHORS:20160513-115213065

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Abstract

Within a few days of fertilization, the sea urchin embryo develops into a small differentiated organism consisting of about 1800 cells and capable of feeding, swimming, and the further ontogenic transformations required in the succeeding weeks of larval growth. A number of distinct cell lineages that are clearly specialized at the morphological and functional levels can be discerned in the advanced embryo, and many of these can be traced back to particular sets of early blastomeres. Classical cell lineage and experimental studies (Hörstadius 1939; for review, see Angerer and Davidson 1984) have shown that certain of these lineages appear to be specified, at least in part, in consequence of the maternal components inherited in those regions of egg cytoplasm occupied by their progenitor cells. Specification of others among the early cell lineages clearly depends on inductive interactions that occur between blastomeres during cleavage. For the molecular biologist, as for his predecessors, this rapidly developing and simply constructed embryo offers the advantages of experimental accessibility. Thus, in respect to direct molecular-level analyses of gene activity in the embryo, for both specific genes and overall transcript populations and their protein products, the sea urchin is at present the best known embryonic system (e.g., reviews of Hentschel and Birnstiel 1981; Davidson et al. 1982; Angerer and Davidson 1984).


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Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1101/SQB.1985.050.01.041 DOIArticle
http://symposium.cshlp.org/content/50/321.extractPublisherArticle
Additional Information:© 1985 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, http://creativecommons.org/licenses/by-nc/4.0/). This work was supported by National Institutes of Health grants HD-05753 and GM-20927. C.N.E was supported by a Lieve Fellowship (S-11-83) from the American Cancer Society, California Division; J.J.R. by a Proctor & Gamble Fellowship; S.J.R. by a Muscular Dystrophy Association Fellowship; and H.M.S. and J.J.L. by a National Institutes of Health training grant (GM-07616).
Funders:
Funding AgencyGrant Number
NIHHD-05753
NIHGM-20927
American Cancer Society, California DivisionS-11-83
Proctor and GambleUNSPECIFIED
Muscular Dystrophy AssociationUNSPECIFIED
NIH Predoctoral FellowshipGM-07616
Record Number:CaltechAUTHORS:20160513-115213065
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160513-115213065
Official Citation:Lineage-specific Gene Expression in the Sea Urchin Embryo E.H. Davidson, C.N. Flytzanis, J.J. Lee, J.J. Robinson, S.J. Rose III, and H.M. Sucov Cold Spring Harb Symp Quant Biol 1985 50: 321-328; doi:10.1101/SQB.1985.050.01.041
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67078
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:13 May 2016 19:07
Last Modified:03 Oct 2019 10:02

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