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Developmental potential of avian trunk neural crest cells in situ

Bronner-Fraser, Marianne and Fraser, Scott (1989) Developmental potential of avian trunk neural crest cells in situ. Neuron, 3 (6). pp. 755-766. ISSN 0896-6273. http://resolver.caltech.edu/CaltechAUTHORS:20160513-130801429

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Abstract

To analyze the developmental potential of individual neural crest cells or their precursors, we have microinjected a vital dye, lysinated rhodamine dextran (LRD), into single cells in the dorsal neural tube. The phenotypes of the descendants that inherited the LRD from the injected cells were evaluated based upon their position, morphology, and neurofilament expression. Individual neural crest cells labeled before or as they emigrated from the neural tube gave rise to both sensory and sympathetic neurons as well as nonneuronal cells, some of which had the morphological characteristics of Schwann cells or pigment cells. In numerous cases, the descendants of a single cell included both neural crest- and neural tube-derived neurons, suggesting that some cells of the peripheral and central nervous systems share a common lineage. Our data demonstrate definitively that both emigrating and premigratory trunk neural crest cells can be multipotent, giving rise not only to cells in multiple neural crest derivatives, but also to both neuronal and nonneuronal elements within a given derivative.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0896-6273(89)90244-4DOIArticle
http://www.sciencedirect.com/science/article/pii/0896627389902444PublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Fraser, Scott0000-0002-5739-4026
Additional Information:© 1989 Cell Press. Received June 6, 1989; revised September 12, 1989. We thank Drs. Andrew Cameron, Gabrielle Leblanc, Katy Lynch, Nancy O'Rourke, John Sechrist, Jes Stollberg, George Serbedzija, and William Todt for helpful comments on the manuscript and Mary Flowers and Scott Burgan for excellent technical assistance. This work was supported by the USPHS (HD-25138) and the Monsanto Corporation.
Funders:
Funding AgencyGrant Number
NIHHD-25138
Monsanto CorporationUNSPECIFIED
Record Number:CaltechAUTHORS:20160513-130801429
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160513-130801429
Official Citation:Marianne Bronner-Fraser, Scott Fraser, Developmental potential of avian trunk neural crest cells in situ, Neuron, Volume 3, Issue 6, December 1989, Pages 755-766, ISSN 0896-6273, http://dx.doi.org/10.1016/0896-6273(89)90244-4. (http://www.sciencedirect.com/science/article/pii/0896627389902444)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67086
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 May 2016 20:16
Last Modified:13 May 2016 20:16

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