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Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo

Krotoski, Danuta M. and Domingo, Carmen and Bronner-Fraser, Marianne (1986) Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo. Journal of Cell Biology, 103 (3). pp. 1061-1071. ISSN 0021-9525. PMCID PMC2114279. https://resolver.caltech.edu/CaltechAUTHORS:20160513-135631179

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Abstract

The cell substratum attachment (CSAT) antibody recognizes a 140-kD cell surface receptor complex involved in adhesion to fibronectin (FN) and laminin (LM) (Horwitz, A., K. Duggan, R. Greggs, C. Decker, and C. Buck, 1985, J. Cell Biol., 101:2134-2144). Here, we describe the distribution of the CSAT antigen along with FN and LM in the early avian embryo. At the light microscopic level, the staining patterns for the CSAT receptor and the extracellular matrix molecules to which it binds were largely codistributed. The CSAT antigen was observed on numerous tissues during gastrulation, neurulation, and neural crest migration: for example, the surface of neural crest cells and the basal surface of epithelial tissues such as the ectoderm, neural tube, notochord, and dermomyotome. FN and LM immunoreactivity was observed in the basement membranes surrounding many of these epithelial tissues, as well as around the otic and optic vesicles. In addition, the pathways followed by cranial neural crest cells were lined with FN and LM. In the trunk region, FN and LM were observed surrounding a subpopulation of neural crest cells. However, neither molecule exhibited the selective distribution pattern necessary for a guiding role in trunk neural crest migration. The levels of CSAT, FN, and LM are dynamic in the embryo, perhaps reflecting that the balance of surface-substratum adhesions contributes to initiation, migration, and localization of some neural crest cell populations.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1083/jcb.103.3.1061DOIArticle
http://jcb.rupress.org/content/103/3/1061.abstractPublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2114279/PubMed CentralArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Additional Information:© 1986 Rockefeller University Press. The Authors acknowledge that RUP will make the Article freely available to the public on RUP’s website after expiration of the Initial Publication Period, and that RUP intends to submit the Article to PubMed Central in accordance with PubMed Central’s requirements, where the Article will be released to the public after expiration of the Initial Publication Period. After the Initial Publication Period, RUP will grant to the public the non- exclusive right to copy, distribute, or display the Work under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license as described at http://creativecommons.org/licenses/by-nc-sa/3.0/ and http://creativecommons.org/licenses/by-nc-sa/3.0/legalcode. Received for publication 14 February 1986, and in revised form 30 May 1986. We thank Drs. Scott Fraser, James Coulombe, Marcia Yaross, and Roberto Perris for their helpful comments on the manuscript. This work was supported by United States Public Health Services grant HD-15527-01 and a Basic Research Grant from the March of Dimes Birth Defects Foundation.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)HD-15527-01
March of Dimes Birth Defects FoundationUNSPECIFIED
Issue or Number:3
PubMed Central ID:PMC2114279
Record Number:CaltechAUTHORS:20160513-135631179
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160513-135631179
Official Citation:Distribution of a putative cell surface receptor for fibronectin and laminin in the avian embryo. D M Krotoski, C Domingo, and M Bronner-Fraser J Cell Biol 1986 103:1061-1071. Published September 1, 1986, doi:10.1083/jcb.103.3.1061
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67088
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 May 2016 19:22
Last Modified:03 Oct 2019 10:02

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