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Molecular recognition of nucleic acid by small molecules. Binding affinity and structural specificity of bis(methidium)spermine

Becker, Michael McClellan and Dervan, Peter B. (1979) Molecular recognition of nucleic acid by small molecules. Binding affinity and structural specificity of bis(methidium)spermine. Journal of the American Chemical Society, 101 (13). pp. 3664-3666. ISSN 0002-7863. http://resolver.caltech.edu/CaltechAUTHORS:20160516-092858958

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Abstract

Nucleic acids are biologically important receptors sufficiently characterized to encourage the syntheses of site specific probes. Molecules capable of binding to nucleic acid templates and interfering with processes in which nucleic acids participate are important in both antibiotic and cancer chemotherapy. Some drugs bind to nucleic acids by intercalation, the insertion of a flat molecule between the base pairs of a double helix. In the absence of unfavorable entropic or steric constraints, an increase in binding affinity and sequence specificity would be expected for polyintercalators which are capable of inserting two or more intercalating units into the nucleic acid double helix.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00507a046DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00507a046PublisherArticle
Additional Information:© 1979 American Chemical Society. Received January 8, 1979. Publication Date: June 1979. We are grateful to the National Institutes of Health (GM-22909), Biomedical Research Support Funds (RR-07003), and the Eli Lilly and Company for generous support.
Funders:
Funding AgencyGrant Number
NIHGM-22909
NIHRR-07003
Eli Lilly and CompanyUNSPECIFIED
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Caltech Crellin Laboratory of Chemistry5924
Record Number:CaltechAUTHORS:20160516-092858958
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160516-092858958
Official Citation:Molecular recognition of nucleic acid by small molecules. Binding affinity and structural specificity of bis(methidium)spermine Michael McClellan Becker and Peter B. Dervan Journal of the American Chemical Society 1979 101 (13), 3664-3666 DOI: 10.1021/ja00507a046
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67104
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:16 May 2016 21:21
Last Modified:16 May 2016 21:21

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