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Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule

Dervan, Peter B. and Becker, Michael M. (1978) Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule. Journal of the American Chemical Society, 100 (6). pp. 1968-1970. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20160516-094027895

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Abstract

The molecular recognition of DNA by small molecules is an important macromolecular receptor-drug interaction in the field of chemotherapy. The formation of noncovalently bound nucleic acid-drug complexes produces profound pharmacological effects by interfering with biological processes in which nucleic acids participate. The fact that DNA is a defined macromolecular receptor allows a rational approach to drug design and permits a unique opportunity for studying site-specific drug-binding processes. The therapeutic importance and the possibility for a detailed chemical understanding of the mechanism of action of these DNA-drug complexes provide sufficient stimulus to develop a rational methodology for optimizing the thermodynamics, kinetics, sequence specificity, structural specificity, and chemical specificity of these binding ligands.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja00474a075DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja00474a075PublisherArticle
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1978 American Chemical Society. Publication Date: March 1978. We are grateful to the National Institutes of Health (GM-22909) and the American Cancer Society, California Division, for generous financial support.
Funders:
Funding AgencyGrant Number
NIHGM-22909
American Cancer Society, California DivisionUNSPECIFIED
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Caltech Crellin Laboratory of Chemistry5706
Issue or Number:6
Record Number:CaltechAUTHORS:20160516-094027895
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160516-094027895
Official Citation:Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule Peter B. Dervan and Michael M. Becker Journal of the American Chemical Society 1978 100 (6), 1968-1970 DOI: 10.1021/ja00474a075
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67109
Collection:CaltechAUTHORS
Deposited By: Victoria Brennan
Deposited On:16 May 2016 21:48
Last Modified:03 Oct 2019 10:03

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