Dervan, Peter B. and Becker, Michael M. (1978) Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule. Journal of the American Chemical Society, 100 (6). pp. 1968-1970. ISSN 0002-7863. doi:10.1021/ja00474a075. https://resolver.caltech.edu/CaltechAUTHORS:20160516-094027895
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Abstract
The molecular recognition of DNA by small molecules is an important macromolecular receptor-drug interaction in the field of chemotherapy. The formation of noncovalently bound nucleic acid-drug complexes produces profound pharmacological effects by interfering with biological processes in which nucleic acids participate. The fact that DNA is a defined macromolecular receptor allows a rational approach to drug design and permits a unique opportunity for studying site-specific drug-binding processes. The therapeutic importance and the possibility for a detailed chemical understanding of the mechanism of action of these DNA-drug complexes provide sufficient stimulus to develop a rational methodology for optimizing the thermodynamics, kinetics, sequence specificity, structural specificity, and chemical specificity of these binding ligands.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1978 American Chemical Society. Publication Date: March 1978. We are grateful to the National Institutes of Health (GM-22909) and the American Cancer Society, California Division, for generous financial support. | |||||||||
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| Issue or Number: | 6 | |||||||||
| DOI: | 10.1021/ja00474a075 | |||||||||
| Record Number: | CaltechAUTHORS:20160516-094027895 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160516-094027895 | |||||||||
| Official Citation: | Molecular recognition of DNA by small molecules. Synthesis of bis(methidium)spermine, a DNA polyintercalating molecule Peter B. Dervan and Michael M. Becker Journal of the American Chemical Society 1978 100 (6), 1968-1970 DOI: 10.1021/ja00474a075 | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 67109 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | Victoria Brennan | |||||||||
| Deposited On: | 16 May 2016 21:48 | |||||||||
| Last Modified: | 11 Nov 2021 00:27 |
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