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Cell lineage analysis reveals multipotency of some avian neural crest cells

Bronner-Fraser, Marianne and Fraser, Scott E. (1988) Cell lineage analysis reveals multipotency of some avian neural crest cells. Nature, 335 (6186). pp. 161-164. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20160516-110121358

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Abstract

A major question in developmental biology is how precursor cells give rise to diverse sets of differentiated cell types. In most systems, it remains unclear whether the precursors can form many or all cell types (multipotent or totipotent), or only a single cell type (predetermined). The question of cell lineage is central to the neural crest because it gives rise to numerous and diverse derivatives including peripheral neurons, glial and Schwann cells, pigment cells, and cartilage. Although the sets of derivatives arising from different populations of neural crest cells have been well-documented, relatively little is known about the developmental potentials of individual neural crest cells. We have iontophoretically microinjected the vital dye, lysinated rhodamine dextran (LRD) into individual dorsal neural tube cells to mark unambiguously their descendants. Many of the resulting labelled clones consisted of multiple cell types, as judged by both their location and morphology. Cells as diverse as sensory neurons, presumptive pigment cells, ganglionic supportive cells, adrenomedullary cells and neural tube cells were found within individual clones. Our results indicate that at least some neural crest cells are multipotent before their departure from the neural tube.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/335161a0DOIArticle
http://www.nature.com/nature/journal/v335/n6186/abs/335161a0.htmlPublisherArticle
ORCID:
AuthorORCID
Bronner-Fraser, Marianne0000-0003-4274-1862
Fraser, Scott E.0000-0002-5739-4026
Additional Information:© 1988 Nature Publishing Group. Received 25 May; accepted 14 July 1988. We thank Drs Gabrielle Leblanc, Roberto Perris, Jes Stollberg, Nancy O'Rourke, Rick Wetts and George Serbedzija for helpful comments, Georgia Guillory and Carmen Domingo for technical assistance and Paige Fraser for support in the early phases of this work. This work was supported by grants from NIH, NSF, March of Dimes and a gift from the Monsanto Corporation. S.E.F. is a McKnight Foundation Scholar. M.B.-F. is a Sloan Research Fellow.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
NSFUNSPECIFIED
March of Dimes FoundationUNSPECIFIED
Monsanto CorporationUNSPECIFIED
McKnight FoundationUNSPECIFIED
Alfred P. Sloan FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20160516-110121358
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160516-110121358
Official Citation:Cell lineage analysis reveals multipotency of some avian neural crest cells MARIANNE BRONNER-FRASER & SCOTT E. FRASER Nature 335, 161 - 164 (08 September 1988); doi:10.1038/335161a0
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67126
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:16 May 2016 19:42
Last Modified:16 May 2016 19:42

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