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Selective Disruption of Gap Junctional Communication Interferes with a Patterning Process in Hydra

Fraser, Scott and Green, Colin R. and Bode, Hans R. and Gilula, Norton B. (1987) Selective Disruption of Gap Junctional Communication Interferes with a Patterning Process in Hydra. Science, 237 (4810). pp. 49-55. ISSN 0036-8075. https://resolver.caltech.edu/CaltechAUTHORS:20160518-105236112

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Abstract

The cells that make up the body column of hydra are extensively joined by gap junctions, capable of mediating the rapid exchange of small hydrophilic molecules between the cytoplasms of neighboring cells. Both the rate of transfer of small molecules through the gap junctions and the rate of return of gap junction coupling after grafting experiments are sufficiently rapid to mediate events in the patterning of hydra tissue. Antibodies to the major rat liver gap junction protein (27,000 daltons) recognize a gap junction antigen in hydra and are effective in eliminating junctional communication between hydra cells. The antibodies perturb the head inhibition gradient in grafting operations, suggesting that cell-cell communication via gap junctions is important in this defined tissue patterning process.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org//10.1126/science.3037697DOIArticle
http://science.sciencemag.org/content/237/4810/49PublisherArticle
ORCID:
AuthorORCID
Fraser, Scott0000-0002-5377-0223
Additional Information:© 1987 American Association for the Advancement of Science. 12 November 1986; accepted 30 April 1987. We thank P. Bode, S. Heimfeld, and L. Javois for helpful discussions and assistance with some of the grafting experiments; and C. Jewell for other excellent assistance. Supported by NSF grants DBC-8510891 and BNS-8406307 (S.E.F.), NIH grant GM-29130 (H.R.B.), and NIH grants GM-32230 and GM-37904 (N.B.G.).
Funders:
Funding AgencyGrant Number
NSFDBC-8510891
NSFBNS-8406307
NIHGM-29130
NIHGM-32230
NIHGM-37904
Issue or Number:4810
Record Number:CaltechAUTHORS:20160518-105236112
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160518-105236112
Official Citation:Selective disruption of gap junctional communication interferes with a patterning process in hydra By SE Fraser, CR Green, HR Bode, NB Gilula Science 03 Jul 1987: Vol. 237, Issue 4810, pp. 49-55 DOI: 10.1126/science.3037697
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67172
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:18 May 2016 18:34
Last Modified:03 Oct 2019 10:03

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