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Oligonucleotide recognition of double-helical DNA by triple-helix formation

Dervan, Peter B. (1989) Oligonucleotide recognition of double-helical DNA by triple-helix formation. In: Oligodeoxynucleotides: Antisense Inhibitors of Gene Expression. Topics in molecular and structural biology. No.12. CRC Press , Boca Raton, FL, pp. 197-210. ISBN 978-1-349-10871-8. http://resolver.caltech.edu/CaltechAUTHORS:20160519-124134048

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Abstract

The sequence-specific recognition of double-helical DNA is an essential biological process responsible for the regulation of cellular functions including transcription, replication and cell division. The ability to design synthetic molecules that bind sequence-specifically to unique sites on human DNA has major implications for the treatment of genetic, oncogenic and viral diseases. A detailed understanding of the chemical principles for binding specific sites on double-helical DNA with oligodeoxynucleotides (or their analogues) by triple-strand formation would provide a pivotal first step in the development of a novel chemotherapeutic strategy of genetic targeting. This could ultimately enable precise inactivation of undesirable DNA sequences within the human genome.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/978-1-349-10869-5_10DOIArticle
http://link.springer.com/chapter/10.1007%2F978-1-349-10869-5_10PublisherArticle
Additional Information:© 1989 CRC Press. We are grateful to the National Institutes of Health and the Office of Naval Research for generous grant support. In addition, unrestricted funds from Burroughs Wellcome, Merck, Hoffmann-La Roche and the Parsons Foundation are gratefully acknowledged.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Office of Naval Research (ONR)UNSPECIFIED
Burroughs-WellcomeUNSPECIFIED
MerckUNSPECIFIED
Hoffmann-La RocheUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20160519-124134048
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160519-124134048
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67184
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 May 2016 20:22
Last Modified:24 May 2016 23:29

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