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The importance of β-alanine for recognition of the minor groove of DNA

Dervan, Peter B. and Urbach, Adam R. (2001) The importance of β-alanine for recognition of the minor groove of DNA. In: From Molecular Structure towards Biology. Essays in Contemporary Chemistry. Verlag Helvetica Chimica Acta , Zürich, Switzerland, pp. 327-339. ISBN 9783906390284.

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It is now well-recognized that there are two global motifs for targeting the minor groove of DNA based on analogs of the N-methylpyrrole-carboxamide ring of the natural product distamycin. There exist 1:1 and 2:1 stoichiometries with quite different rules of recognition and specificity. This ambiguity of sequence targeting depending on stoichiometry raises a serious design issue for the DNA recognition field.

Item Type:Book Section
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Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 2001 Verlag Helvetica Chimica Acta. We are grateful to the National Institutes of Health for support.
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Subject Keywords:recognition of the minor groove of DNA, β-alanine
Series Name:Essays in Contemporary Chemistry
Record Number:CaltechAUTHORS:20160519-124235592
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Official Citation:Dervan, P. B. and Urbach, A. R. (2001) The Importance of β-Alanine for Recognition of the Minor Groove of DNA, in Essays in Contemporary Chemistry: From Molecular Structure towards Biology (eds G. Quinkert and M. V. Kisakürek), Verlag Helvetica Chimica Acta, Zürich. doi: 10.1002/9783906390451.ch9
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67188
Deposited By: George Porter
Deposited On:20 May 2016 17:53
Last Modified:26 Nov 2019 11:15

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