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Synthetic sequence specific DNA binding molecules

Dervan, Peter B. and Youngquist, R. Scott and Sluka, James P. (1987) Synthetic sequence specific DNA binding molecules. In: Stereochemistry of organic and bioorganic transformations. VCH , New York, NY, pp. 221-234. ISBN 0895736071. https://resolver.caltech.edu/CaltechAUTHORS:20160519-124245836

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Abstract

The design of sequence specific DNA-binding molecules has advanced in recent years due, in part, to the development of analytical techniques such as footprinting and affinity cleaving which allow rapid and precise analysis of hundreds of of potential DNA binding sites. The construction of synthetic molecules that bind in the minor and major groove of DNA with incrementally increasing sequence specificity is simply the first step toward developing a set of rules for the three-dimensional readout of double helical DNA.


Item Type:Book Section
ORCID:
AuthorORCID
Dervan, Peter B.0000-0001-8852-7306
Additional Information:© 1987 VCH. We are very grateful for the generous support of the National Institutes of Health, the American Cancer Society, the National Foundation for Cancer Research, the DARPA University Research Initiative Program, Burroughs-Wellcome Company, the Allied-Signal Corporation and the Smith Kline Beckman Corporation.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
American Cancer SocietyUNSPECIFIED
National Foundation for Cancer ResearchUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Burroughs-WellcomeUNSPECIFIED
Allied-SignalUNSPECIFIED
Smith Kline BeckmanUNSPECIFIED
Record Number:CaltechAUTHORS:20160519-124245836
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160519-124245836
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67189
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 May 2016 18:07
Last Modified:26 Nov 2019 11:15

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