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Multipotent precursors can give rise to all major cell types of the frog retina

Wetts, Richard and Fraser, S. E. (1988) Multipotent precursors can give rise to all major cell types of the frog retina. Science, 239 (4844). pp. 1142-1145. ISSN 0036-8075. http://resolver.caltech.edu/CaltechAUTHORS:20160520-110417054

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Abstract

A prospective lineage analysis was performed to determine the variety of cell types that could be formed by individual precursor cells of the developing frog retina. Fluorescent dextran was iontophoretically injected into single cells of the embryonic optic vesicle. After further development of the embryo, labeled descendants were observed in all three layers of the larval retina. Furthermore, different clones were composed of various combinations of all major cell types, including the glial Muller cells. Hence, single optic vesicle cells have the potential to form any type of retinal cell, suggesting that the interactions that specify the differentiation pathway of retinal cells must occur late in development.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1126/science.2449732DOIArticle
http://science.sciencemag.org/content/239/4844/1142PublisherArticle
ORCID:
AuthorORCID
Fraser, S. E.0000-0002-5739-4026
Additional Information:© 1988 American Association for the Advancement of Science. 19 October 1987; accepted 20 January 1988. Supported by NSF, the McKnight Foundation, and the Monsanto Corporation.
Funders:
Funding AgencyGrant Number
NSFUNSPECIFIED
McKnight FoundationUNSPECIFIED
Monsanto CorporationUNSPECIFIED
Record Number:CaltechAUTHORS:20160520-110417054
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160520-110417054
Official Citation:Multipotent precursors can give rise to all major cell types of the frog retina By R Wetts, SE Fraser Science 04 Mar 1988 : 1142-1145
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67204
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:20 May 2016 18:12
Last Modified:20 May 2016 18:12

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