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Synthetic Tools for Molecular Biology

Dervan, Peter B. (1988) Synthetic Tools for Molecular Biology. In: Biotechnology and materials science : chemistry for the future. American Chemical Society , Washington, DC, pp. 21-29. ISBN 9780841214736. http://resolver.caltech.edu/CaltechAUTHORS:20160520-130857609

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Abstract

Chemistry has made tremendous advances over the past four decades in the broad fields of synthesis and understanding chemical reactivity. In that same time span, a series of revolutionary events occurred in biology. First came the discovery of the double helical structure of DNA in the 1950s by Watson and Crick. This discovery allowed the elucidation of the mechanisms of DNA replication -- how DNA makes copies of itself -- and DNA transcription and translation -- the processes that allow the genetic code to be read and translated into proteins. In the 1970s, the techniques that permit DNA to be cut and spliced in controlled and well-defined ways were invented and the technology of recombinant DNA was born.


Item Type:Book Section
Additional Information:© 1988 American Chemical Society. The author is grateful to the National Institutes of Health, the American Cancer Society, the DARPA University Initiative Research Program, Allied Signal Corporation, Merck Sharp & Dohme, Research Laboratories, Burroughs-Wellcome Company and the Ralph M. Parsons Foundation for generous support. In addition, stimulating and helpful discussions with Dr. Ralph Hisrchmann are gratefully acknowledged.
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Funding AgencyGrant Number
NIHUNSPECIFIED
American Cancer SocietyUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Allied SignalUNSPECIFIED
Merck Sharp & Dohme Research LaboratoriesUNSPECIFIED
Burroughs-WellcomeUNSPECIFIED
Ralph M. Parsons FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20160520-130857609
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160520-130857609
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67212
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 May 2016 20:32
Last Modified:24 May 2016 23:00

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