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Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA

Griffin, John H. and Dervan, Peter B. (1989) Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA. In: Metal ion homeostasis : molecular biology and chemistry. UCLA symposia on molecular and cellular biology. No.98. Alan R. Liss , New York, NY, pp. 21-30. ISBN 9780845126974. http://resolver.caltech.edu/CaltechAUTHORS:20160520-134443882

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Abstract

The design, synthesis, and DNA binding studies of a series of bis(netropsin)s linked by homologous polyether tethers has been undertaken. DNA affinity cleaving experiments show that one compound, bis(netropsin)-3,6,9,12,15-pentaoxahepta-decanediamine-EDTA:Fe(II) (1b:Fe(II)) is positively activated for specific DNA binding in the presence of Sr^(2+) or Ba^(2+) ions. The effects of linker structure, metal ion concentration, and DNA sequence on the metalloregulated binding are reported.


Item Type:Book Section
Additional Information:© 1989 Alan R. Liss. This work was supported by NIH and by NSF and Merck Sharpe & Dohme/ACS fellowships to JHG.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
NSFUNSPECIFIED
Merck Sharp & Dohme Research LaboratoriesUNSPECIFIED
American Chemical SocietyUNSPECIFIED
Record Number:CaltechAUTHORS:20160520-134443882
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160520-134443882
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67215
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 May 2016 21:00
Last Modified:24 May 2016 23:08

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