Griffin, John H. and Dervan, Peter B. (1989) Metalloregulation in the Sequence Specific Binding of Synthetic Molecules to DNA. In: Metal ion homeostasis : molecular biology and chemistry. UCLA symposia on molecular and cellular biology. No.98. Alan R. Liss , New York, NY, pp. 21-30. ISBN 9780845126974. https://resolver.caltech.edu/CaltechAUTHORS:20160520-134443882
Full text is not posted in this repository.
Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160520-134443882
Abstract
The design, synthesis, and DNA binding studies of a series of bis(netropsin)s linked by homologous polyether tethers has been undertaken. DNA affinity cleaving experiments show that one compound, bis(netropsin)-3,6,9,12,15-pentaoxahepta-decanediamine-EDTA:Fe(II) (1b:Fe(II)) is positively activated for specific DNA binding in the presence of Sr^(2+) or Ba^(2+) ions. The effects of linker structure, metal ion concentration, and DNA sequence on the metalloregulated binding are reported.
| Item Type: | Book Section | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ORCID: |
| ||||||||||
| Additional Information: | © 1989 Alan R. Liss. This work was supported by NIH and by NSF and Merck Sharpe & Dohme/ACS fellowships to JHG. | ||||||||||
| Funders: |
| ||||||||||
| Series Name: | UCLA symposia on molecular and cellular biology | ||||||||||
| Issue or Number: | 98 | ||||||||||
| Record Number: | CaltechAUTHORS:20160520-134443882 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160520-134443882 | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 67215 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | George Porter | ||||||||||
| Deposited On: | 20 May 2016 21:00 | ||||||||||
| Last Modified: | 26 Nov 2019 11:15 |
Repository Staff Only: item control page
