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Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174

Merriam, Virginia and Funk, Fred and Sinsheimer, Robert L. (1971) Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 12 (2). pp. 206-210. ISSN 0027-5107. https://resolver.caltech.edu/CaltechAUTHORS:20160520-140511516

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Abstract

The role of the parental viral strand in infection with bacteriophage Φ174 has been deduced from both biophysical and biological studies. The viral strand, on entering the cell, is converted to a double-stranded replicative form (RF). This parental RF is bound to the membrane, where the viral strand appears to be physically conserved throughout infection and to be required even at late times. In starved cells, only the RF containing the parental viral strand replicates, semiconservatively. The parental viral strand is conserved in this RF, with each new complementary partner being released in turn in a progeny RF molecule. The parental RF is also responsible for initial messenger RNA synthesis; it is not yet known whether or not it is responsible for all messenger RNA synthesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0027-5107(71)90144-8DOIArticle
http://www.sciencedirect.com/science/article/pii/0027510771901448PublisherArticle
Additional Information:© 1971 Elsevier. Received 9 February 1971. This research was supported in part by a grant GM 13554 from the U.S. Public Health Service.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM 13554
Issue or Number:2
Record Number:CaltechAUTHORS:20160520-140511516
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160520-140511516
Official Citation:Virginia Merriam, Fred Funk, Robert L. Sinsheimer, Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 12, Issue 2, June 1971, Pages 206-210, ISSN 0027-5107, http://dx.doi.org/10.1016/0027-5107(71)90144-8. (http://www.sciencedirect.com/science/article/pii/0027510771901448)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67217
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:20 May 2016 21:10
Last Modified:03 Oct 2019 10:04

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