Merriam, Virginia and Funk, Fred and Sinsheimer, Robert L. (1971) Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 12 (2). pp. 206-210. ISSN 0027-5107. doi:10.1016/0027-5107(71)90144-8. https://resolver.caltech.edu/CaltechAUTHORS:20160520-140511516
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Abstract
The role of the parental viral strand in infection with bacteriophage Φ174 has been deduced from both biophysical and biological studies. The viral strand, on entering the cell, is converted to a double-stranded replicative form (RF). This parental RF is bound to the membrane, where the viral strand appears to be physically conserved throughout infection and to be required even at late times. In starved cells, only the RF containing the parental viral strand replicates, semiconservatively. The parental viral strand is conserved in this RF, with each new complementary partner being released in turn in a progeny RF molecule. The parental RF is also responsible for initial messenger RNA synthesis; it is not yet known whether or not it is responsible for all messenger RNA synthesis.
| Item Type: | Article | |||||||||
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| Additional Information: | © 1971 Elsevier. Received 9 February 1971. This research was supported in part by a grant GM 13554 from the U.S. Public Health Service. | |||||||||
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| Issue or Number: | 2 | |||||||||
| DOI: | 10.1016/0027-5107(71)90144-8 | |||||||||
| Record Number: | CaltechAUTHORS:20160520-140511516 | |||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160520-140511516 | |||||||||
| Official Citation: | Virginia Merriam, Fred Funk, Robert L. Sinsheimer, Genetic expression in whole cells of heterozygous replicative-form molecules of Φ174, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 12, Issue 2, June 1971, Pages 206-210, ISSN 0027-5107, http://dx.doi.org/10.1016/0027-5107(71)90144-8. (http://www.sciencedirect.com/science/article/pii/0027510771901448) | |||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
| ID Code: | 67217 | |||||||||
| Collection: | CaltechAUTHORS | |||||||||
| Deposited By: | George Porter | |||||||||
| Deposited On: | 20 May 2016 21:10 | |||||||||
| Last Modified: | 11 Nov 2021 00:29 |
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