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Patterns of dye coupling in the imaginal wing disk of Drosophila melanogaster

Fraser, Scott E. and Bryant, Peter J. (1985) Patterns of dye coupling in the imaginal wing disk of Drosophila melanogaster. Nature, 317 (6037). pp. 533-536. ISSN 0028-0836. https://resolver.caltech.edu/CaltechAUTHORS:20160523-065057095

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Abstract

Responses of developing tissues to experimental disruption demonstrate that cell interaction is important both in generating positional information and in controlling growth. However, the mechanism by which cells interact and the range over which the interactions are effective are not known. In the imaginai disks of Drosophila melanogaster, experiments on pattern regulation following surgical ablation suggest that the cell interactions are very local in nature; in fact, most of the data can be explained by assuming that cells interact only with their immediate neighbours. In contrast, studies of cell division patterns in the same tissue indicate that the ‘local’ proliferative response to an ablation extends over a distance of up to about eight cell diameters. Still longer-range interactions have been proposed on the basis of theoretical considerations. It is possible that the interactions are mediated by the transfer of small molecules through gap junctions, as gap junctions are abundant in imaginai disks at the appropriate developmental stages. We have explored the range, timing and directionality of dye coupling between the cells of the wing disk as a test of the possible role of gap junctions in imaginai disk patterning. Our results indicate that interactions over different ranges are possible depending on the nature of the molecule being transferred.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/317533a0DOIArticle
http://www.nature.com/nature/journal/v317/n6037/abs/317533a0.htmlPublisherArticle
ORCID:
AuthorORCID
Fraser, Scott E.0000-0002-5377-0223
Additional Information:© 1985 Nature Publishing Group. Received 5 July; accepted 6 August 1985. This investigation was supported by NIH grant HD06082 and NSF grants BNS 80-23638 and BNS 84-06307.
Funders:
Funding AgencyGrant Number
NIHHD-06082
NSFBNS 80-23638
NFSBNS 84-06307
Issue or Number:6037
Record Number:CaltechAUTHORS:20160523-065057095
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160523-065057095
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67233
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:23 May 2016 19:02
Last Modified:03 Oct 2019 10:04

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