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Phase-field model for collective cell migration

Najem, Sara and Grant, Martin (2016) Phase-field model for collective cell migration. Physical Review E, 93 (5). Art. No. 052405. ISSN 2470-0045.

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We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.

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Additional Information:© 2016 American Physical Society. Received 10 November 2015; published 9 May 2016. We acknowledge support from the Natural Sciences and Engineering Research Council of Canada, le Fonds de recherche du Québec—Nature et technologies, and discussions with Iain Couzin and members of the Couzin Lab at Princeton University.
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Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Fonds de recherche du Québec-Nature et Technologies (FRQ-NT)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20160525-105207767
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Official Citation:Phase-field model for collective cell migration Sara Najem and Martin Grant Phys. Rev. E 93, 052405
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67347
Deposited By: Tony Diaz
Deposited On:26 May 2016 19:40
Last Modified:03 Oct 2019 10:05

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