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Phase-field model for collective cell migration

Najem, Sara and Grant, Martin (2016) Phase-field model for collective cell migration. Physical Review E, 93 (5). Art. No. 052405. ISSN 2470-0045. https://resolver.caltech.edu/CaltechAUTHORS:20160525-105207767

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Abstract

We construct a phase-field model for collective cell migration based on a Ginzburg-Landau free-energy formulation. We model adhesion, surface tension, repulsion, coattraction, and polarization, enabling us to follow the cells' morphologies and the effect of their membranes fluctuations on collective motion. We were able to measure the tissue surface tension as a function of the individual cell cortical tension and adhesion and identify a density threshold for cell-sheet formation.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1103/PhysRevE.93.052405DOIArticle
http://journals.aps.org/pre/abstract/10.1103/PhysRevE.93.052405PublisherArticle
Additional Information:© 2016 American Physical Society. Received 10 November 2015; published 9 May 2016. We acknowledge support from the Natural Sciences and Engineering Research Council of Canada, le Fonds de recherche du Québec—Nature et technologies, and discussions with Iain Couzin and members of the Couzin Lab at Princeton University.
Funders:
Funding AgencyGrant Number
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Fonds de recherche du Québec-Nature et Technologies (FRQ-NT)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20160525-105207767
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160525-105207767
Official Citation:Phase-field model for collective cell migration Sara Najem and Martin Grant Phys. Rev. E 93, 052405
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:67347
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 May 2016 19:40
Last Modified:03 Oct 2019 10:05

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